KEGG   ENZYME: 4.2.3.11Help
Entry
EC 4.2.3.11                 Enzyme                                 

Name
sabinene-hydrate synthase;
sabinene hydrate cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
Reaction(IUBMB)
geranyl diphosphate + H2O = sabinene hydrate + diphosphate [RN:R02006]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
sabinene hydrate [CPD:C02462];
diphosphate [CPD:C00013]
Comment
Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction
History
EC 4.2.3.11 created 1992 as EC 4.6.1.9, transferred 2000 to EC 4.2.3.11
Pathway
Monoterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1  [PMID:3401015]
  Authors
Hallahan TW, Croteau R.
  Title
Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis).
  Journal
Arch. Biochem. Biophys. 264 (1988) 618-31.
Reference
2  [PMID:2916845]
  Authors
Hallahan TW, Croteau R.
  Title
Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate.
  Journal
Arch. Biochem. Biophys. 269 (1989) 313-26.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117164-95-1

DBGET integrated database retrieval system