KEGG   ENZYME: 4.2.3.136Help
Entry
EC 4.2.3.136                Enzyme                                 

Name
alpha-isocomene synthase;
MrTPS2
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-alpha-isocomene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate [RN:R10272]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-isocomene [CPD:C20477];
diphosphate [CPD:C00013]
Comment
Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids.
History
EC 4.2.3.136 created 2012
Reference
1  [PMID:22682202]
  Authors
Irmisch S, Krause ST, Kunert G, Gershenzon J, Degenhardt J, Kollner TG
  Title
The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils.
  Journal
BMC. Plant. Biol. 12 (2012) 84.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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