KEGG   ENZYME: 4.2.3.139Help
Entry
EC 4.2.3.139                Enzyme                                 

Name
valerena-4,7(11)-diene synthase;
VoTPS2;
VoTPS7
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, valerena-4,7(11)-diene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = valerena-4,7(11)-diene + diphosphate [RN:R10275]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
valerena-4,7(11)-diene [CPD:C20480];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene.
History
EC 4.2.3.139 created 2012
Reference
1  [PMID:22776156]
  Authors
Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, MacNevin G, Vederas JC, Kim SU, Ro DK
  Title
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase  from the valerian plant (Valeriana officinalis).
  Journal
FEBS. J. 279 (2012) 3136-46.
  Sequence
Reference
2  [PMID:23243312]
  Authors
Yeo YS, Nybo SE, Chittiboyina AG, Weerasooriya AD, Wang YH, Gongora-Castillo E, Vaillancourt B, Buell CR, DellaPenna D, Celiz MD, Jones AD, Wurtele ES, Ransom N, Dudareva N, Shaaban KA, Tibrewal N, Chandra S, Smillie T, Khan IA, Coates RM, Watt DS, Chappell J
  Title
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.
  Journal
J. Biol. Chem. 288 (2013) 3163-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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