Entry |
|
Name |
|
Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
 |
Sysname |
(13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol forming)
|
Reaction(IUBMB) |
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O = sclareol + diphosphate [RN: R10241]
|
Reaction(KEGG) |
|
Substrate |
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD: C20270];
H2O [CPD: C00001]
|
Product |
|
Comment |
Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery.
|
History |
EC 4.2.3.141 created 2013, modified 2017
|
Pathway |
| Diterpenoid biosynthesis | | Biosynthesis of secondary metabolites |
|
Orthology |
|
Reference |
|
Authors |
Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, Bohlmann J, Legendre L |
Title |
Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. |
Journal |
BMC. Plant. Biol. 12 (2012) 119. |
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |