KEGG   ENZYME: 4.2.3.141Help
Entry
EC 4.2.3.141                Enzyme                                 

Name
sclareol synthase;
SS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol forming)
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O = sclareol + diphosphate [RN:R10241]
Reaction(KEGG)
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270];
H2O [CPD:C00001]
Product
sclareol [CPD:C09183];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery.
History
EC 4.2.3.141 created 2013, modified 2017
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K20519  
sclareol synthase
Reference
1  [PMID:22834731]
  Authors
Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, Bohlmann J, Legendre L
  Title
Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture.
  Journal
BMC. Plant. Biol. 12 (2012) 119.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system