KEGG   ENZYME: 4.2.3.143Help
Entry
EC 4.2.3.143                Enzyme                                 

Name
kunzeaol synthase;
TgTPS2 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (kunzeaol forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate [RN:R10493]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
kunzeaol [CPD:C20576];
diphosphate [CPD:C00013]
Comment
Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase.
History
EC 4.2.3.143 created 2013
Reference
1  [PMID:22938155]
  Authors
Pickel B, Drew DP, Manczak T, Weitzel C, Simonsen HT, Ro DK
  Title
Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin.
  Journal
Biochem. J. 448 (2012) 261-71.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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