KEGG   ENZYME: 4.2.3.145Help
Entry
EC 4.2.3.145                Enzyme                                 

Name
ophiobolin F synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, ophiobolin-F-forming)
Reaction(IUBMB)
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate [RN:R10762]
Reaction(KEGG)
Substrate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate [CPD:C04217];
H2O [CPD:C00001]
Product
ophiobolin F [CPD:C16818];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid).
History
EC 4.2.3.145 created 2014
Orthology
K18685  
ophiobolin F synthase
Genes
ACT: 
CIM: 
CPW: 
BZE: 
BSC: 
BOR: 
Taxonomy
Reference
1  [PMID:23324037]
  Authors
Chiba R, Minami A, Gomi K, Oikawa H
  Title
Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus.
  Journal
Org. Lett. 15 (2013) 594-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system