KEGG   ENZYME: 4.2.3.146Help
Entry
EC 4.2.3.146                Enzyme                                 

Name
cyclooctat-9-en-7-ol synthase;
cetB2
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclooctat-9-en-7-ol-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate [RN:R10763]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
cyclooctat-9-en-7-ol [CPD:C20834];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.
History
EC 4.2.3.146 created 2014
Orthology
K18686  
cyclooctat-9-en-7-ol synthase
Genes
SVL: 
SCI: 
SRC: 
Taxonomy
Reference
1  [PMID:19635410]
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem. Biol. 16 (2009) 736-43.
  Sequence
Reference
2  [PMID:24598929]
  Authors
Zhang X, Shang G, Gu L, Shen Y
  Title
Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35.
  Journal
Acta. Crystallogr. F. Struct. Biol. Commun. 70 (2014) 366-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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