KEGG   ENZYME: 4.2.3.19Help
Entry
EC 4.2.3.19                 Enzyme                                 

Name
ent-kaurene synthase;
ent-kaurene synthase B;
ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-kaurene + diphosphate [RN:R05092]
Reaction(KEGG)
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-kaurene [CPD:C06090];
diphosphate [CPD:C00013]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC 5.5.1.13 (ent-copalyl diphosphate synthase)
History
EC 4.2.3.19 created 2002
Pathway
Diterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K04121  
ent-kaurene synthase
K20657  
ent-copalyl diphosphate/ent-kaurene synthase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0250739.1(Lj0g3v0250739.1) Lj0g3v0250739.2(Lj0g3v0250739.2) Lj3g3v0948400.1(Lj3g3v0948400.1) Lj3g3v0948400.2(Lj3g3v0948400.2) Lj3g3v0948400.4(Lj3g3v0948400.4)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
101217426(CsKS1)
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4336959(KS2) 4336960(KS1A) 4336962(KSL2)
DOSA: 
Os02t0568700-00(Os02g0568700) Os02t0572050-00(Os02g0572050) Os04t0611700-00(Os04g0611700) Os04t0611800-00(Os04g0611800) Os04t0612000-00(Os04g0612000) Os11t0474800-01(Os11g0474800)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_05g022320(SORBIDRAFT_05g022320) SORBI_06g028220(SORBIDRAFT_06g028220)
ZMA: 
100279558 100383607(GRMZM2G016922) 103645955(GRMZM2G093603)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
MGR: 
BZE: 
BSC: 
BOR: 
 » show all
Taxonomy
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J. Biol. Chem. 246 (1971) 6913-28.
Reference
2  [PMID:8771778]
  Authors
Yamaguchi S, Saito T, Abe H, Yamane H, Murofushi N, Kamiya Y.
  Title
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.).
  Journal
Plant. J. 10 (1996) 203-13.
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y.
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J. Biol. Chem. 272 (1997) 21706-12.
  Sequence
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T.
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci. Biotechnol. Biochem. 64 (2000) 660-4.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9055-64-5

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