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Entry
EC 4.2.3.25                 Enzyme                                 

Name
S-linalool synthase;
LIS;
Lis;
3S-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3S)-linalool + diphosphate [RN:R07631]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3S)-linalool [CPD:C11389];
diphosphate [CPD:C00013]
Comment
Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed.
History
EC 4.2.3.25 created 2006
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K15086  
(3S)-linalool synthase
K22049  
S-linalool synthase
Genes
ATH: 
AT1G61680(TPS14)
ALY: 
CSAT: 
THJ: 
GMX: 
MTR: 
CSV: 
RCU: 
8267425(RcSeTPS13)
VVI: 
SLY: 
101244812(TPS37) 101245403(TPS39)
OSA: 
4328124(LIS)
DOSA: 
Os02t0121700-01(Os02g0121700)
BDI: 
SBI: 
ZMA: 
732758(TPS2)
 » show all
Taxonomy
Reference
1  [PMID:7864636]
  Authors
Pichersky E, Lewinsohn E, Croteau R.
  Title
Purification and characterization of S-linalool synthase, an enzyme involved in the production of floral scent in Clarkia breweri.
  Journal
Arch. Biochem. Biophys. 316 (1995) 803-7.
Reference
2  [PMID:11532177]
  Authors
Lucker J, Bouwmeester HJ, Schwab W, Blaas J, van der Plas LH, Verhoeven HA.
  Title
Expression of Clarkia S-linalool synthase in transgenic petunia plants results in the accumulation of S-linalyl-beta-D-glucopyranoside.
  Journal
Plant. J. 27 (2001) 315-24.
Reference
3  [PMID:8768373]
  Authors
Dudareva N, Cseke L, Blanc VM, Pichersky E.
  Title
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower.
  Journal
Plant. Cell. 8 (1996) 1137-48.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
160477-81-6

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