KEGG   ENZYME: 4.2.3.28Help
Entry
EC 4.2.3.28                 Enzyme                                 

Name
ent-cassa-12,15-diene synthase;
OsDTC1;
OsKS7
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate [RN:R09119]
Reaction(KEGG)
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-cassa-12,15-diene [CPD:C18226];
diphosphate [CPD:C00013]
Comment
This class I diterpene cyclase produces ent-cassa-12,15-diene, a precursor of the rice phytoalexins (-)-phytocassanes A-E. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
History
EC 4.2.3.28 created 2008
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K14036  
ent-cassa-12,15-diene synthase
Genes
OSA: 
4329724(DTC1)
DOSA: 
Os02t0570400-01(Os02g0570400)
Taxonomy
Reference
1  [PMID:14675427]
  Authors
Cho EM, Okada A, Kenmoku H, Otomo K, Toyomasu T, Mitsuhashi W, Sassa T, Yajima A, Yabuta G, Mori K, Oikawa H, Toshima H, Shibuya N, Nojiri H, Omori T, Nishiyama M, Yamane H.
  Title
Molecular cloning and characterization of a cDNA encoding ent-cassa-12,15-diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension-cultured rice cells treated with a chitin elicitor.
  Journal
Plant. J. 37 (2004) 1-8.
  Sequence
[osa:4329724]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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