KEGG   ENZYME: 4.2.3.34Help
Entry
EC 4.2.3.34                 Enzyme                                 

Name
stemod-13(17)-ene synthase;
OsKSL11;
stemodene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming]
Reaction(IUBMB)
9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate [RN:R09116]
Reaction(KEGG)
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
stemod-13(17)-ene [CPD:C18224];
diphosphate [CPD:C00013]
Comment
This enzyme catalyses the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity. The enzyme also produces stemod-12-ene and stemar-13-ene as minor products.
History
EC 4.2.3.34 created 2008
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K14045  
stemod-13(17)-ene synthase
Reference
1  [PMID:16256063]
  Authors
Morrone D, Jin Y, Xu M, Choi SY, Coates RM, Peters RJ.
  Title
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase.
  Journal
Arch. Biochem. Biophys. 448 (2006) 133-40.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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