KEGG   ENZYME: 4.2.3.37Help
Entry
EC 4.2.3.37                 Enzyme                                 

Name
epi-isozizaene synthase;
SCO5222 protein
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate [RN:R07830]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-epi-isozizaene [CPD:C16269];
diphosphate [CPD:C00013]
Comment
Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K10156  
epi-isozizaene synthase
Genes
SCO: 
SCO5222(SC7E4.19)
SMA: 
SAV_3032(tpc2)
Taxonomy
Reference
1  [PMID:16669656]
  Authors
Lin X, Hopson R, Cane DE.
  Title
Genome mining in streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.
  Journal
J. Am. Chem. Soc. 128 (2006) 6022-3.
  Organism
Streptomyces coelicolor [GN:sco]
  Sequence
[sco:SCO5222]
Reference
2  [PMID:18234666]
  Authors
Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE
  Title
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
  Journal
J. Biol. Chem. 283 (2008) 8183-9.
  Organism
Streptomyces coelicolor [GN:sco]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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