KEGG   ENZYME: 4.2.3.48Help
Entry
EC 4.2.3.48                 Enzyme                                 

Name
(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.48 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14175  (3S,6E)-nerolidol synthase
Genes
THJ: 104809526
CIT: 102617431 102617651 102617908 102620886
CIC: CICLE_v10004558mg CICLE_v10014632mg CICLE_v10014707mg
TCC: 108662607 18597023 18597024
GRA: 105777993
GHI: 107924963 107940942
DZI: 111281010 111318783
EGR: 104445481 104447370 104447372 104447373 104447374 104447375 104447392 104447394 104447396 104447399 108957334
GMX: 100783015 100814957
PVU: PHAVU_002G219100g PHAVU_002G219300g PHAVU_006G195600g PHAVU_006G195700g
VRA: 106765590 106766355 106766356 106766374 106768047 106774503 106774972
VAR: 108326386 108338184 108338349 108342452
CCAJ: 109814060 109814089 109817871 109817878
MTR: MTR_3g052120 MTR_3g063120 MTR_3g063140 MTR_3g063160 MTR_3g465090 MTR_4g092010 MTR_4g092020 MTR_6g065040
CAM: 101494917 101495251 101495572 101503644 101505365 101515140
ADU: 107468546 107468547 107468751 107480611
AIP: 107622334 107622335 107622336 107622340 107623232 107626247 110267972
LJA: Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2) Lj0g3v0198989.3(Lj0g3v0198989.3) Lj0g3v0306569.1(Lj0g3v0306569.1) Lj6g3v2135290.1(Lj6g3v2135290.1)
LANG: 109334775
FVE: 101299453 101302321 105349289
PPER: 18778181
PMUM: 103324596 103343969
PAVI: 110747962 110752892 110768753
MDM: 103434640 103446597 103446598(LIS)
PXB: 103941370 103941371 103958297 108866779
ZJU: 107421470 107421878
CSV: 101215070
CMO: 103485748 103485753 103485759 103489227
MCHA: 111010706 111010875 111010876 111010887
CMAX: 111484385 111490118 111495716
CMOS: 111434067 111434068 111447175 111456834
RCU: 8259987(RcSeTPS4)
JCU: 105629808 105629819 105629820 105649410 105649411
HBR: 110635396 110644414 110654947 110661963
JRE: 108979322 108979323 109004685 109004686 109004723 109007398 109013445 109013447 109015330
VVI: 100248531 100266449(LinNer) 100267150 100852561 100852596 100852776 100853562 100853639 100853679 100854717 100854809 104878270 104878271 104878369
SPEN: 107019618
SOT: 102580873 102592813
CANN: 107845646
NTA: 107828192
NTO: 104117466
INI: 109163834 109167275 109167276 109167277 109167278 109167279
SIND: 105156792 105175396 105175430 105175469 105175470
OEU: 111395219 111396005 111396009 111396015 111396016
HAN: 110884314 110887780 110889629 110915780 110916766 110919641
BVG: 104883052 104901069 104901071
SOE: 110789690 110789691
NNU: 104591086 104591099
SITA: 101782336
AOF: 109820753
ATR: 18440985 18440990
 » show all
Taxonomy
Reference
1  [PMID:15522848]
  Authors
Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ
  Title
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.
  Journal
Plant. Cell. 16 (2004) 3110-31.
Reference
2  [PMID:10482672]
  Authors
Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M
  Title
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.
  Journal
Plant. Physiol. 121 (1999) 173-80.
Reference
3  [PMID:10805454]
  Authors
Degenhardt J, Gershenzon J
  Title
Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.
  Journal
Planta. 210 (2000) 815-22.
Reference
4  [PMID:17924138]
  Authors
Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W
  Title
Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of  jasmonate, ethylene and calcium signaling.
  Journal
Planta. 227 (2008) 453-64.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.48
IUBMB Enzyme Nomenclature: 4.2.3.48
ExPASy - ENZYME nomenclature database: 4.2.3.48
BRENDA, the Enzyme Database: 4.2.3.48
DBGET integrated database retrieval system