KEGG   ENZYME: 4.2.3.52Help
Entry
EC 4.2.3.52                 Enzyme                                 

Name
(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing);
phellandrene synthase;
(-)-beta-phellandrene synthase;
(-)-(4S)-beta-phellandrene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing; (4S)-beta-phellandrene-forming]
Reaction(IUBMB)
geranyl diphosphate = (4S)-beta-phellandrene + diphosphate
Substrate
geranyl diphosphate [CPD:C00341]
Product
(4S)-beta-phellandrene;
diphosphate [CPD:C00013]
Comment
Requires Mn2+. Mg2+ is not effective [1]. Some (-)-alpha-phellandrene is also formed [3]. The reaction involves a 1,3-hydride shift [4].
History
EC 4.2.3.52 created 2010
Reference
1  [PMID:8307957]
  Authors
Savage TJ, Hatch MW, Croteau R
  Title
Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase.
  Journal
J. Biol. Chem. 269 (1994) 4012-20.
Reference
2  [PMID:10441373]
  Authors
Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R
  Title
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
  Journal
Arch. Biochem. Biophys. 368 (1999) 232-43.
  Sequence
Reference
3
  Authors
Wagschal, K., Savage, T.J. and Croteau, R.
  Title
Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases.
  Journal
Tetrahedron 31 (1991) 5933-5944.
Reference
4  [PMID:8460944]
  Authors
LaFever RE, Croteau R
  Title
Hydride shifts in the biosynthesis of the p-menthane monoterpenes alpha-terpinene, gamma-terpinene, and beta-phellandrene.
  Journal
Arch. Biochem. Biophys. 301 (1993) 361-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
137010-34-5

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