KEGG   ENZYME: 4.2.3.6Help
Entry
EC 4.2.3.6                  Enzyme                                 

Name
trichodiene synthase;
trichodiene synthetase;
sesquiterpene cyclase;
trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate [RN:R02306]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
trichodiene [CPD:C01860];
diphosphate [CPD:C00013]
History
EC 4.2.3.6 created 1989 as EC 4.1.99.6, transferred 2000 to EC 4.2.3.6
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K12249  
trichodiene synthase
Genes
FGR: 
AOR: 
AOR_1_710014(AO090026000382)
AFV: 
NFI: 
Taxonomy
Reference
1  [PMID:3800398]
  Authors
Hohn TM, Vanmiddlesworth F.
  Title
Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides.
  Journal
Arch. Biochem. Biophys. 251 (1986) 756-61.
  Organism
Fusarium sporotrichioides
Reference
2  [PMID:2777086]
  Authors
Hohn TM, Beremand PD
  Title
Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides.
  Journal
Gene. 79 (1989) 131-8.
  Organism
Fusarium sporotrichioides
  Sequence
[up:P13513]
Reference
3  [PMID:11698643]
  Authors
Rynkiewicz MJ, Cane DE, Christianson DW
  Title
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13543-8.
  Organism
Fusarium sporotrichioides
  Sequence
[up:P13513]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
101915-76-8

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