KEGG   ENZYME: 4.2.3.70Help
Entry
EC 4.2.3.70                 Enzyme                                 

Name
patchoulol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = patchoulol + diphosphate [RN:R09629]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
patchoulol [CPD:C19755];
diphosphate [CPD:C00013]
History
EC 4.2.3.70 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15807  
patchoulol/alpha-guaiene/delta-guaiene synthase
Reference
1  [PMID:3038029]
  Authors
Croteau R, Munck SL, Akoh CC, Fisk HJ, Satterwhite DM
  Title
Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf  extracts of Pogostemon cablin (patchouli): mechanistic considerations.
  Journal
Arch. Biochem. Biophys. 256 (1987) 56-68.
  Sequence
Reference
2  [PMID:2171435]
  Authors
Munck SL, Croteau R
  Title
Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin.
  Journal
Arch. Biochem. Biophys. 282 (1990) 58-64.
  Sequence
Reference
3  [PMID:20148554]
  Authors
Faraldos JA, Wu S, Chappell J, Coates RM
  Title
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase.
  Journal
J. Am. Chem. Soc. 132 (2010) 2998-3008.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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