KEGG   ENZYME: 4.2.3.75Help
Entry
EC 4.2.3.75                 Enzyme                                 

Name
(-)-germacrene D synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-germacrene-D-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate [RN:R07648]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-germacrene D [CPD:C16142];
diphosphate [CPD:C00013]
Comment
In Solidago canadensis the biosynthesis results in the pro-R hydrogen at C-1 of the farnesy diphosphate ending up at C-11 of the (-)-germacrene D [1]. With Streptomyces coelicolor the pro-S hydrogen at C-1 ends up at C-11 of the (-)-germacrene D [2].
History
EC 4.2.3.75 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K10187  
germacradienol/geosmin synthase
K15803  
(-)-germacrene D synthase
Genes
CRB: 
CSAT: 
BNA: 
BOE: 
CPAP: 
CIT: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0102559.1(Lj0g3v0102559.1) Lj0g3v0116739.1(Lj0g3v0116739.1) Lj0g3v0168849.1(Lj0g3v0168849.1) Lj0g3v0221889.1(Lj0g3v0221889.1)
FVE: 
PPER: 
PMUM: 
PAVI: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
MCHA: 
RCU: 
8259975 8282483(RcSeTPS3)
JCU: 
HBR: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
NSY: 
NTO: 
INI: 
SIND: 
HAN: 
BVG: 
SOE: 
NNU: 
DOSA: 
Os07t0218200-00(Os07g0218200)
OBR: 
BDI: 
ATS: 
109732008(LOC109732008) 109750167(LOC109750167) 109760189(LOC109760189) 109760190(LOC109760190) 109760191(LOC109760191) 109768109(LOC109768109) 109774711(LOC109774711) 109777990(LOC109777990) 109779437(LOC109779437) 109785129(LOC109785129) 109785753(LOC109785753) 109786027(LOC109786027)
SBI: 
ZMA: 
SITA: 
EGU: 
MUS: 
DCT: 
CPRA: 
MXA: 
MFU: 
MSD: 
MYM: 
MMAS: 
CCX: 
SUR: 
STAUR_1114(geoA2)
AGE: 
MBD: 
CFUS: 
SCL: 
SCU: 
CCRO: 
MRM: 
HOH: 
NBR: 
SCO: 
SCO6073(SC9B1.20)
SMA: 
SGR: 
SGR_6839(geoA)
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
SLE: 
sle_16070(sle_16070)
SRN: 
SPAV: 
SLC: 
STRT: 
SCLF: 
SGS: 
STSI: 
SLS: 
SNR: 
SPLU: 
STRD: 
SNW: 
SAUO: 
SSIA: 
SVU: 
SPUN: 
SGV: 
SMAL: 
SLAU: 
KSK: 
KSE_46080(geoA)
KAB: 
KAU: 
KFL: 
NGV: 
SRO: 
NOA: 
FRA: 
FRE: 
FRI: 
FAL: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
ALU: 
AMI: 
APRE: 
SESP: 
BN6_11180(geoA)
KAL: 
KPHY: 
LED: 
ALL: 
PMAD: 
CAI: 
SNA: 
AEY: 
NPU: 
CSG: 
CALO: 
 » show all
Taxonomy
Reference
1
  Authors
Schmidt, C.O., Bouwmeester, H.J., Franke, S. and Konig, W.A.
  Title
Mechanisms of the biosynthesis of sesquiterpene enantiomers (+)- and (-)-germacrene D in Solidago canadensis.
  Journal
Chirality 11 (1999) 353-362.
Reference
2  [PMID:14995166]
  Authors
He X, Cane DE.
  Title
Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2).
  Journal
J. Am. Chem. Soc. 126 (2004) 2678-9.
  Sequence
[sco:SCO6073]
Reference
3  [PMID:15464152]
  Authors
Lucker J, Bowen P, Bohlmann J.
  Title
Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries.
  Journal
Phytochemistry. 65 (2004) 2649-59.
  Sequence
[vvi:100232954]
Reference
4  [PMID:15542052]
  Authors
Prosser I, Altug IG, Phillips AL, Konig WA, Bouwmeester HJ, Beale MH
  Title
Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif.
  Journal
Arch. Biochem. Biophys. 432 (2004) 136-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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