KEGG   ENZYME: 4.2.3.8Help
Entry
EC 4.2.3.8                  Enzyme                                 
Name
casbene synthase;
casbene synthetase;
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = casbene + diphosphate [RN:R02064]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
casbene [CPD:C01414];
diphosphate [CPD:C00013]
Comment
The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.
Pathway
Diterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K12929  
casbene synthase
Genes
RCU: 
Taxonomy
Reference
1  [PMID:3985625]
  Authors
Moesta P, West CA.
  Title
Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation.
  Journal
Arch. Biochem. Biophys. 238 (1985) 325-33.
  Organism
Ricinus communis [GN:rcu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69106-45-2
DBGET integrated database retrieval system