KEGG   ENZYME: 4.2.3.8Help
Entry
EC 4.2.3.8                  Enzyme                                 

Name
casbene synthase;
casbene synthetase;
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = casbene + diphosphate [RN:R02064]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
casbene [CPD:C01414];
diphosphate [CPD:C00013]
Comment
The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.
History
EC 4.2.3.8 created 1989 as EC 4.6.1.7, transferred 2000 to EC 4.2.3.8
Pathway
Diterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K12929  
casbene synthase
Genes
RCU: 
Taxonomy
Reference
1  [PMID:3985625]
  Authors
Moesta P, West CA.
  Title
Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation.
  Journal
Arch. Biochem. Biophys. 238 (1985) 325-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69106-45-2

DBGET integrated database retrieval system