KEGG   ENZYME: 4.2.3.86Help
Entry
EC 4.2.3.86                 Enzyme                                 

Name
7-epi-alpha-selinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-alpha-selinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = 7-epi-alpha-selinene + diphosphate [RN:R09886]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
7-epi-alpha-selinene [CPD:C20159];
diphosphate [CPD:C00013]
Comment
The recombinant enzyme from Vitis vinifera forms 49.5% (+)-valencene (cf. EC 4.2.3.73, valencene synthase) and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.
History
EC 4.2.3.86 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14181  
valencene/7-epi-alpha-selinene synthase
Genes
VVI: 
Taxonomy
Reference
1  [PMID:15464152]
  Authors
Lucker J, Bowen P, Bohlmann J.
  Title
Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries.
  Journal
Phytochemistry. 65 (2004) 2649-59.
  Sequence
[vvi:100232955]
Reference
2  [PMID:19359488]
  Authors
Martin DM, Toub O, Chiang A, Lo BC, Ohse S, Lund ST, Bohlmann J
  Title
The bouquet of grapevine (Vitis vinifera L. cv. Cabernet Sauvignon) flowers arises from the biosynthesis of sesquiterpene volatiles in pollen grains.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 7245-50.
  Sequence
[vvi:100232955]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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