KEGG   ENZYME: 4.2.3.95Help
Entry
EC 4.2.3.95                 Enzyme                                 

Name
(-)-alpha-cuprenene synthase;
Cop6
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(-)-alpha-cuprenene hydrolase [cyclizing, (-)-alpha-cuprenene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate [RN:R09895]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-cuprenene [CPD:C20180];
diphosphate [CPD:C00013]
Comment
The enzyme from the fungus Coprinopsis cinerea produces (-)-alpha-cuprenene with high selectivity.
History
EC 4.2.3.95 created 2012
Reference
1  [PMID:20419721]
  Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
  Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
  Journal
Chembiochem. 11 (2010) 1093-106.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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