KEGG   ENZYME: 4.2.3.96Help
Entry
EC 4.2.3.96                 Enzyme                                 

Name
avermitilol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
avermitilol hydrolase (cyclizing, avermitilol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate [RN:R09896]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
avermitilol [CPD:C20181];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.
History
EC 4.2.3.96 created 2012
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18110  
avermitilol synthase
Genes
SMA: 
SAV_76(tpc1)
STRM: 
Taxonomy
Reference
1  [PMID:20536237]
  Authors
Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
  Journal
J. Am. Chem. Soc. 132 (2010) 8850-1.
  Sequence
[sma:SAV_76]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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