KEGG   ENZYME: 4.2.3.98Help
Entry
EC 4.2.3.98                 Enzyme                                 

Name
(+)-T-muurolol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate [RN:R09898]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-T-muurolol [CPD:C20184];
diphosphate [CPD:C00013]
Comment
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.
History
EC 4.2.3.98 created 2012
Reference
1  [PMID:21276937]
  Authors
Hu Y, Chou WK, Hopson R, Cane DE
  Title
Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.
  Journal
Chem. Biol. 18 (2011) 32-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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