KEGG   ENZYME: 4.3.1.16Help
Entry
EC 4.3.1.16                 Enzyme                                 

Name
threo-3-hydroxy-L-aspartate ammonia-lyase;
L-threo-3-hydroxyaspartate dehydratase;
threo-3-hydroxyaspartate ammonia-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)
Reaction(IUBMB)
threo-3-hydroxy-L-aspartate = oxaloacetate + NH3 [RN:R05758]
Reaction(KEGG)
Substrate
threo-3-hydroxy-L-aspartate [CPD:C11511]
Product
oxaloacetate [CPD:C00036];
NH3 [CPD:C00014]
Comment
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Pseudomonas sp. T62, is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, or Ca2+.
History
EC 4.3.1.16 created 2001, modified 2011
Reference
1  [PMID:10481099]
  Authors
Wada M, Matsumoto T, Nakamori S, Sakamoto M, Kataoka M, Liu JQ, Itoh N, Yamada H, Shimizu S.
  Title
Purification and characterization of a novel enzyme, L-threo-3-hydroxyaspartate dehydratase, from Pseudomonas sp. T62.
  Journal
FEMS. Microbiol. Lett. 179 (1999) 147-51.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
248270-70-4

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