KEGG   ENZYME: 4.3.1.22Help
Entry
EC 4.3.1.22                 Enzyme                                 

Name
3,4-dihydroxyphenylalanine reductive deaminase;
reductive deaminase;
DOPA-reductive deaminase;
DOPARDA
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)
Reaction(IUBMB)
L-dopa + 2 NADH = 3,4-dihydroxyphenylpropanoate + 2 NAD+ + NH3 [RN:R08846]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
NADH [CPD:C00004]
Product
3,4-dihydroxyphenylpropanoate [CPD:C10447];
NAD+ [CPD:C00003];
NH3 [CPD:C00014]
Comment
Forms part of the L-phenylalanine-catabolism pathway in the anoxygenic phototrophic bacterium Rhodobacter sphaeroides OU5. NADPH is oxidized more slowly than NADH.
History
EC 4.3.1.22 created 2007
Pathway
Tyrosine metabolism
Reference
1  [PMID:17616348]
  Authors
Ranjith NK, Sasikala Ch, Ramana ChV.
  Title
Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine.
  Journal
Res. Microbiol. 158 (2007) 506-11.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system