KEGG   ENZYME: 4.3.1.4Help
Entry
EC 4.3.1.4                  Enzyme                                 

Name
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
Reaction(IUBMB)
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN:R02302]
Reaction(KEGG)
Substrate
5-formimidoyltetrahydrofolate [CPD:C00664]
Product
5,10-methenyltetrahydrofolate [CPD:C00445];
NH3 [CPD:C00014]
Comment
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
Pathway
One carbon pool by folate
Metabolic pathways
Orthology
K01746  
formiminotetrahydrofolate cyclodeaminase
K13990  
glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase
Genes
HSA: 
10841(FTCD)
PTR: 
474057(FTCD)
PPS: 
100977170(FTCD)
GGO: 
101130780(FTCD)
PON: 
MCF: 
102134897(FTCD)
MMU: 
14317(Ftcd)
RNO: 
89833(Ftcd)
CGE: 
HGL: 
101712457(Ftcd)
TUP: 
102471947(FTCD)
CFA: 
607685(FTCD)
AML: 
FCA: 
101080907(FTCD)
BTA: 
535816(FTCD)
BOM: 
102278178(FTCD)
PHD: 
102342678(FTCD)
CHX: 
102175530(FTCD)
SSC: 
397517(FTCD)
CFR: 
102517308(FTCD)
ECB: 
100049972(FTCD)
MYB: 
102245572(FTCD)
MDO: 
SHR: 
100933669(FTCD)
OAA: 
GGA: 
395726(FTCD)
MGP: 
TGU: 
100221117(FTCD)
FAB: 
101820680(FTCD)
PHI: 
APLA: 
101789783(FTCD)
FPG: 
101910482(FTCD)
FCH: 
102051629(FTCD)
CLV: 
102087672(FTCD)
ASN: 
102375778(FTCD)
PSS: 
102463032(FTCD)
ACS: 
XLA: 
379483(ftcd)
XTR: 
448617(ftcd)
DRE: 
394052(ftcd)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362862(FTCD)
BFO: 
CIN: 
SPU: 
NVE: 
AQU: 
DDI: 
DPP: 
DFA: 
DFA_10621(ftcd)
DPS: 
DAT: 
HRM2_43160(ftcD1) HRM2_44060(ftcD2)
DTO: 
SPY: 
SPZ: 
SPM: 
SPG: 
SPS: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
SPA: 
SPB: 
SOZ: 
SSA: 
SGO: 
SDS: 
CTC: 
AMT: 
OVA: 
TEP: 
TOC: 
ABA: 
SUS: 
FNU: 
GAU: 
BACC: 
OSP: 
PMZ: 
PDN: 
PIT: 
AFD: 
ASH: 
HHY: 
SGN: 
FLI: 
OHO: 
IAL: 
MRO: 
HAU: 
ATM: 
NDE: 
TTR: 
HMA: 
pNG7381(ftc)
PTO: 
ABI: 
ACF: 
 » show all
Taxonomy
Reference
1
  Authors
Rabinowitz, J.C. and Pricer, W.E.
  Title
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid.
  Journal
J. Am. Chem. Soc. 78 (1956) 5702-5704.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-05-7

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