KEGG   ENZYME: 4.3.2.4Help
Entry
EC 4.3.2.4                  Enzyme                                 

Name
purine imidazole-ring cyclase;
DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing);
DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing;
DNA-adenine-forming)
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)
Reaction(IUBMB)
DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O [RN:R02960]
Reaction(KEGG)
R02960;
(other) R08403
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Substrate
DNA 4,6-diamino-5-formamidopyrimidine [CPD:C04381]
Product
DNA adenine [CPD:C00821];
H2O [CPD:C00001]
Comment
Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by gamma-rays.
History
EC 4.3.2.4 created 1989
Reference
1  [PMID:3856219]
  Authors
Chetsanga CJ, Grigorian C.
  Title
In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 633-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
95990-28-6

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