| Entry |
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| Name |
strictosidine synthase;
strictosidine synthetase;
STR;
3-alpha(S)-strictosidine tryptamine-lyase
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| Class |
Lyases;
Carbon-nitrogen lyases;
Amine-lyases
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| Sysname |
3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)
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| Reaction(IUBMB) |
3-alpha(S)-strictosidine + H2O = tryptamine + secologanin [RN: R03738]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.
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| Pathway |
| Indole alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
DME: | | ATH: | | ALY: | | RHA: | | LIL: | | LIC: | | LBL: | |
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| Reference |
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| Authors |
Treimer JF, Zenk MH. |
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| Title |
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. |
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| Journal |
Eur. J. Biochem. 101 (1979) 225-33. |
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| Organism |
Catharanthus roseus |
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| Reference |
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| Authors |
Kutchan TM. |
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| Title |
Strictosidine: from alkaloid to enzyme to gene. |
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| Journal |
Phytochemistry. 32 (1993) 493-506. |
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| Organism |
Catharanthus roseus, Rauvolfia serpentina |
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| Reference |
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| Authors |
de Waal A, Meijer AH, Verpoorte R. |
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| Title |
Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms. |
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| Journal |
Biochem. J. 306 ( Pt 2) (1995) 571-80. |
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| Organism |
Catharanthus roseus |
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| Reference |
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| Authors |
Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stockigt J. |
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| Title |
Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system. |
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| Journal |
Planta. 222 (2005) 888-98. |
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| Organism |
Rauvolfia serpentina |
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| Reference |
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| Authors |
McCoy E, Galan MC, O'Connor SE. |
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| Title |
Substrate specificity of strictosidine synthase. |
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| Journal |
Bioorg. Med. Chem. Lett. 16 (2006) 2475-8. |
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| Organism |
Catharanthus roseus |
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| Reference |
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| Authors |
Ma X, Panjikar S, Koepke J, Loris E, Stockigt J. |
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| Title |
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins. |
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| Journal |
Plant. Cell. 18 (2006) 907-20. |
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| Organism |
Rauvolfia serpentina |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 69669-72-3 |
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