KEGG   ENZYME: 4.3.3.2Help
Entry
EC 4.3.3.2                  Enzyme                                 

Name
strictosidine synthase;
strictosidine synthetase;
STR;
3-alpha(S)-strictosidine tryptamine-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amine-lyases
BRITE hierarchy
Sysname
3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)
Reaction(IUBMB)
3-alpha(S)-strictosidine + H2O = tryptamine + secologanin [RN:R03738]
Reaction(KEGG)
Substrate
3-alpha(S)-strictosidine [CPD:C03470];
H2O [CPD:C00001]
Product
tryptamine [CPD:C00398];
secologanin [CPD:C01852]
Comment
Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.
History
EC 4.3.3.2 created 1990
Pathway
Indole alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01757  
strictosidine synthase
Genes
DME: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
RHA: 
LIL: 
LIC: 
LBL: 
Taxonomy
Reference
1  [PMID:510306]
  Authors
Treimer JF, Zenk MH.
  Title
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation.
  Journal
Eur. J. Biochem. 101 (1979) 225-33.
Reference
2  [PMID:7763429]
  Authors
Kutchan TM.
  Title
Strictosidine: from alkaloid to enzyme to gene.
  Journal
Phytochemistry. 32 (1993) 493-506.
Reference
3  [PMID:7887913]
  Authors
de Waal A, Meijer AH, Verpoorte R.
  Title
Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms.
  Journal
Biochem. J. 306 ( Pt 2) (1995) 571-80.
Reference
4  [PMID:16133216]
  Authors
Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stockigt J.
  Title
Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system.
  Journal
Planta. 222 (2005) 888-98.
Reference
5  [PMID:16481164]
  Authors
McCoy E, Galan MC, O'Connor SE.
  Title
Substrate specificity of strictosidine synthase.
  Journal
Bioorg. Med. Chem. Lett. 16 (2006) 2475-8.
Reference
6  [PMID:16531499]
  Authors
Ma X, Panjikar S, Koepke J, Loris E, Stockigt J.
  Title
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins.
  Journal
Plant. Cell. 18 (2006) 907-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69669-72-3

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