KEGG   ENZYME: 4.3.99.2Help
Entry
EC 4.3.99.2                 Enzyme                                 

Name
carboxybiotin decarboxylase;
MadB;
carboxybiotin protein decarboxylase
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
BRITE hierarchy
Sysname
carboxybiotinyl-[protein] carboxy-lyase
Reaction(IUBMB)
a carboxybiotinyl-[protein] + n Na+in + H+out = CO2 + a biotinyl-[protein] + n Na+out (n = 1--2) [RN:R09509]
Reaction(KEGG)
Substrate
carboxybiotinyl-[protein] [CPD:C18047];
Na+ [CPD:C01330];
H+ [CPD:C00080]
Product
CO2 [CPD:C00011];
biotinyl-[protein] [CPD:C18046];
Na+out (n = 1--2)
Comment
The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 4.1.1.3 (oxaloacetate decarboxylase) and EC 4.1.1.41 (methylmalonyl-CoA decarboxylase) [2].
History
EC 4.3.99.2 created 2008
Orthology
K20509  
carboxybiotin decarboxylase
Genes
EFE: 
KPZ: 
KPB: 
CAMA: 
SFO: 
DES: 
RPB: 
RPC: 
RCP: 
RRU: 
RRF: 
ATI: 
PFT: 
 » show all
Taxonomy
Reference
1  [PMID:9128730]
  Authors
Berg M, Hilbi H, Dimroth P
  Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
  Journal
Eur. J. Biochem. 245 (1997) 103-15.
  Sequence
Reference
2  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol. Microbiol. 25 (1997) 3-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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