| Entry |
|
| Name |
7-carboxy-7-deazaguanine synthase;
7-carboxy-7-carbaguanine synthase;
queE (gene name)
|
| Class |
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
 |
| Sysname |
6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
|
| Reaction(IUBMB) |
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3 [RN: R10002]
|
| Reaction(KEGG) |
|
| Substrate |
6-carboxy-5,6,7,8-tetrahydropterin [CPD: C20239]
|
| Product |
|
| Comment |
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of queuosine.
|
| Pathway |
| Folate biosynthesis | | Metabolic pathways |
|
| Orthology |
| 7-carboxy-7-deazaguanine synthase |
|
| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | BAS: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SSZ: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | HDE: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | SECT: | | SEHC: | | EBF: | | XFA: | | XFT: | | XFM: | | XFN: | | XFF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | CJA: | | AVN: | | AVL: | | AVD: | | PAR: | | PCR: | | PRW: | | ACI: | | ACD: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | MCT: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | ILO: | | CPS: | | PHA: | | PAT: | | PSM: | | SDE: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | GPS: | | PIN: | | PSY: | | TTU: | | FBL: | | CBU: | | CBS: | | CBD: | | CBG: | | CBC: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | MCA: | | MMT: | | MAH: | | MEJ: | | MEC: | | CYQ: | | NOC: | | NHL: | | NWA: | | TMB: | | TGR: | | TKM: | | TNI: | | HNA: | | ABO: | | ADI: | | KKO: | | AHA: | | ASA: | | AVR: | | TAU: | | OCE: | | AFE: | | AFR: | | ACU: | | AFI: | | BCI: | | SAGA: | | RMA: | | GPB: | | BPH: | | BPX: | | NEU: | | NET: | | NIT: | | NII: | | NMU: | | EBA: | | AZO: | | AZA: | | TMZ: | | DSU: | | TBD: | | MFA: | | MMB: | | MEH: | | MEI: | | MEP: | | APP: | | SLT: | | GCA: | | DMA: | | BBAT: | | BEX: | | BMX: | | DPS: | | DAK: | | DPR: | | DSF: | | DOL: | | DAL: | | DTO: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | SAT: | | DAO: | | DTI: | | SFU: | | DBR: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMB: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | MNO: | | SIL: | | SIT: | | PDE: | | PSF: | | PGA: | | PGL: | | MGM: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BHA: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BCL: | | BPU: | | BPF: | | BMQ: | | BMD: | | BMH: | | BSE: | | BCO: | | BCK: | | BAG: | | BJS: | | OIH: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SEP: | | SER: | | SHA: | | SSP: | | SCA: | | SLG: | | SLN: | | SSD: | | SDT: | | SWA: | | LSP: | | HHD: | | ESI: | | EAT: | | EAN: | | MCL: | | BBE: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | AAC: | | AAD: | | BTS: | | SMU: | | SMC: | | SMJ: | | SMUT: | | STC: | | STL: | | STE: | | STN: | | STU: | | STW: | | SGA: | | SGG: | | SGT: | | SMB: | | SOR: | | STB: | | SSR: | | STF: | | STJ: | | STD: | | SMN: | | SIF: | | CAE: | | CAY: | | CTH: | | CTX: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBB: | | CBI: | | CBF: | | CBM: | | CBJ: | | CBE: | | CCB: | | CLS: | | CLB: | | CCL: | | CAD: | | CSR: | | DAE: | | DED: | | DEC: | | EEL: | | BFI: | | CCT: | | RAL: | | RTO: | | BPRL: | | CSC: | | ATE: | | COB: | | CHD: | | COW: | | CKI: | | CKN: | | CLC: | | TNR: | | AAR: | | VPR: | | MED: | | AFN: | | AIN: | | PUV: | | WCH: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | TPX: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | CTM: | | OSP: | | FSU: | | FSC: | | IPO: | | OTE: | | MIN: | | PSL: | | PLM: | | PBS: | | IPA: | | SACI: | | CPC: | | CPH: | | CPB: | | CLI: | | PVI: | | PPH: | | PAA: | | CTS: | | IAL: | | TYE: | | NDE: | | LFC: | | LFI: | | TID: | | TOP: | | MOX: | | MHU: | | MLA: | | MEM: | | MBG: | | MPI: | | MBN: | | MFO: | | MPL: | | HAL: | | HSL: | | HMA: | | HHI: | | HLA: | | HMU: | | HTU: | | NMG: | | HVO: | | HME: | | HJE: | | HBO: | | HXA: | | NAT: | | NPE: | | NGE: | | NOU: | | TAR: | | ABI: | | ACF: | | MAX: | | PIS: | | HAH: | | » show all
 |
| Reference |
|
| Authors |
McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V |
| Title |
The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps. |
| Journal |
Biochemistry. 48 (2009) 3847-52. |
| Organism |
Bacillus subtilis [GN: bsu] |
| Sequence |
|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |