KEGG   ENZYME: 4.3.99.4Help
Entry
EC 4.3.99.4                 Enzyme                                 

Name
choline trimethylamine-lyase;
cutC (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
BRITE hierarchy
Sysname
choline trimethylamine-lyase (acetaldehyde-forming)
Reaction(IUBMB)
choline = trimethylamine + acetaldehyde [RN:R10285]
Reaction(KEGG)
Substrate
choline [CPD:C00114]
Product
trimethylamine [CPD:C00565];
acetaldehyde [CPD:C00084]
Comment
The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria.
History
EC 4.3.99.4 created 2013
Orthology
K20038  choline trimethylamine-lyase
Genes
ECP: ECP_4600
ECI: UTI89_C4964
ECT: ECIAI39_4211
EOC: CE10_4248
ELU: UM146_22045
EFE: EFER_1995
KPE: KPK_4883
KPR: KPR_0821
KPB: FH42_20250
KVA: Kvar_4520
KOX: KOX_09770
KOE: A225_0656
EAE: EAE_10070
EAR: CCG31976
LEI: C2U54_12990(cutC)
EBF: D782_3573
SMAF: D781_0477
ECA: ECA3768
PATR: EV46_18475
PATO: GZ59_37640
PCT: PC1_3543
PEC: W5S_3855
PMR: PMI2716
PRG: RB151_038860(bssA)
PALA: CO695_06855(cutC)
AHA: AHA_1330
PCA: Pcar_0937
DDS: Ddes_1357
DEF: CNY67_08905(cutC)
DPS: DP1823
SDA: GGS_1829(pflD)
SIE: SCIM_0634
SIK: K710_0229
CTC: CTC_01449
CBO: CBO2118
CBA: CLB_2055
CBH: CLC_2060
CBY: CLM_2326
CBL: CLK_1571
CBK: CLL_A1453
CBB: CLD_2523
CBI: CLJ_B2322
CBN: CbC4_1734
CBT: CLH_1376
CBF: CLI_2161
CBM: CBF_2145
CKL: CKL_3002
CKR: CKR_2652
CLJ: CLJU_c39830(pflB3)
CLS: CXIVA_14340(PflD)
CBV: U729_818
CLD: CLSPO_c21310(pflD1)
CACE: CACET_c30180(pflD3)
CPY: Cphy_1417
CPRO: CPRO_22300(bssA)
CDF: CD630_11200(pflD)
CDC: CD196_0973(dhaB1)
CDL: CDR20291_0951(dhaB1)
PDF: CD630DERM_11200(pflD)
EAC: EAL2_808p07030(pflD)
DSY: DSY5006
DHD: Dhaf_4905
DRM: Dred_3278
PFT: JBW_03217
AIN: Acin_2025(pflD)
OLS: Olsu_0306
LOKI: Lokiarch_36490(bssA_3)
 » show all
Taxonomy
Reference
1  [PMID:23151509]
  Authors
Craciun S, Balskus EP
  Title
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 109 (2012) 21307-12.
  Sequence
[dde:Dde_3282] [dds:Ddes_1357]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.4
IUBMB Enzyme Nomenclature: 4.3.99.4
ExPASy - ENZYME nomenclature database: 4.3.99.4
BRENDA, the Enzyme Database: 4.3.99.4

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