KEGG   ENZYME: 4.4.1.19Help
Entry
EC 4.4.1.19                 Enzyme                                 

Name
phosphosulfolactate synthase;
(2R)-phospho-3-sulfolactate synthase;
(2R)-O-phospho-3-sulfolactate sulfo-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming)
Reaction(IUBMB)
(2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite [RN:R07476]
Reaction(KEGG)
Substrate
(2R)-2-O-phospho-3-sulfolactate
Product
phosphoenolpyruvate [CPD:C00074];
sulfite [CPD:C00094]
Comment
Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.
History
EC 4.4.1.19 created 2003
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K08097  phosphosulfolactate synthase
Genes
LOK: Loa_02095 Loa_02096
BOH: AKI39_05310
DPG: DESPIGER_2203
AVI: Avi_9196
XAU: Xaut_4872 Xaut_5052 Xaut_5069
AMV: ACMV_19940
BSU: BSU10950(yitD)
BSR: I33_1230(yitD)
BSL: A7A1_0911
BSH: BSU6051_10950(yitD)
BSUT: BSUB_01192(yitD)
BSUL: BSUA_01192(yitD)
BSUS: Q433_06185
BSS: BSUW23_05550(yitD)
BST: GYO_1401(yitD)
BSQ: B657_10950(slpS)
BSX: C663_1118(comA)
BLI: BL02005(yitD)
BLD: BLi02155(yitD)
BLH: BaLi_c22300(yitD)
BATR: TD68_02710
BCK: BCO26_1398(yitD)
BAG: Bcoa_3122
BCOA: BF29_414(yitD)
BJS: MY9_1193
BACY: QF06_04410
BACL: BS34A_12090(yitD)
BALM: BsLM_1140
BGY: BGLY_2293(yitD)
BBE: BBR47_23190(comA)
PMW: B2K_14740
PLV: ERIC2_c33000(comA)
PSWU: SY83_19300
AAD: TC41_1228 TC41_2723(comA)
BTS: Btus_1783
OOE: OEOE_0441
STH: STH2643
DRM: Dred_1677
DAE: Dtox_2359
PTH: PTH_1816
DAU: Daud_1309
HMO: HM1_0946
TMR: Tmar_1045
SAY: TPY_1196(comA)
MTA: Moth_0118
ADG: Adeg_1603
LPIL: LIP_0779
SALS: SLNWT_0539
CWO: Cwoe_0088
HAU: Haur_1567
SUS: Acid_4865
SRU: SRU_0020
SRM: SRM_00021(comA)
RMR: Rmar_0022
FLN: FLA_0115
PHE: Phep_4158
MUC: MuYL_0731
MGOT: MgSA37_00444(yitD)
CHU: CHU_0004
DFE: Dfer_4445
SLI: Slin_0707
LBY: Lbys_3154
FAE: FAES_0308
HSW: Hsw_3670
FLM: MY04_3220
MJA: MJ_0255
MMP: MMP0273(comA)
MMD: GYY_01400
MAE: Maeo_0153
MVO: Mvol_1330
MTH: MTH_1674
MMG: MTBMA_c02530(comA)
METC: MTCT_1527
MWO: MWSIV6_0212(comA)
METE: tca_01621(yitD)
MST: Msp_1270(comA)
MSI: Msm_0086
MEB: Abm4_0691(comA)
MMIL: sm9_0980(comA)
MEYE: TL18_05470
MOL: YLM1_0878
METH: MBMB1_0449(comA)
MFC: BRM9_1809(comA)
MFI: DSM1535_2450(comA)
MCUB: MCBB_0411(comA)
MFV: Mfer_1060
MKA: MK0394(comA)
TAA: NMY3_01362(yitD_1) NMY3_02409(yitD_2)
 » show all
Taxonomy
Reference
1  [PMID:11830598]
  Authors
Graham DE, Xu H, White RH.
  Title
Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.
  Journal
J. Biol. Chem. 277 (2002) 13421-9.
  Sequence
[mja:MJ_0255]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.19
IUBMB Enzyme Nomenclature: 4.4.1.19
ExPASy - ENZYME nomenclature database: 4.4.1.19
BRENDA, the Enzyme Database: 4.4.1.19
CAS: 473575-53-0

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