KEGG   ENZYME: 4.4.1.22Help
Entry
EC 4.4.1.22                 Enzyme                                 

Name
S-(hydroxymethyl)glutathione synthase;
glutathione-dependent formaldehyde-activating enzyme;
Gfa;
S-(hydroxymethyl)glutathione formaldehyde-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)
Reaction(IUBMB)
S-(hydroxymethyl)glutathione = glutathione + formaldehyde [RN:R06982]
Reaction(KEGG)
Substrate
S-(hydroxymethyl)glutathione [CPD:C14180]
Product
glutathione [CPD:C00051];
formaldehyde [CPD:C00067]
Comment
The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.
History
EC 4.4.1.22 created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 4.4.1.22)
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K03396  
S-(hydroxymethyl)glutathione synthase
Genes
PHD: 
SMP: 
PAN: 
TTT: 
TMN: 
FGR: 
FPU: 
NHE: 
MAJ: 
VAL: 
VDA: 
ELA: 
AOR: 
ANG: 
ANI_1_14024(An02g00080)
AFV: 
PCS: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
XCC: 
XCB: 
XCA: 
XCP: 
XCV: 
XAC: 
XCI: 
XCT: 
XCU: 
XCN: 
XCW: 
XCR: 
XCM: 
XCF: 
XCJ: 
XFU: 
XAX: 
XAO: 
XOM: 
XOO3646(XOO3646)
XOP: 
XOZ: 
XSA: 
XTN: 
DTX: 
VFI: 
VFM: 
VSA: 
PPR: 
PRE: 
PPX: 
PSB: 
PPUU: 
PKC: 
SFR: 
SSE: 
SPL: 
SHL: 
SWD: 
SVO: 
PSY: 
MVS: 
HHU: 
BAM: 
BAC: 
BPY: 
AKA: 
AMIM: 
VEI: 
MMS: 
MLO: 
MOP: 
MAM: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SMD: 
RHI: 
SFH: 
SFD: 
EAD: 
RET: 
REC: 
REL: 
REI: 
REP: 
RLE: 
RLT: 
RLG: 
RLB: 
RLU: 
RHL: 
RGA: 
SHZ: 
BJA: 
BJU: 
BJP: 
BRA: 
BBT: 
BRS: 
AOL: 
BRC: 
RPC: 
RPE: 
RSP: 
RSH: 
RSQ: 
RSK: 
PDE: 
PAMI: 
ACR: 
AMV: 
MAGQ: 
PGV: 
AFE: 
AFR: 
AFI: 
SIV: 
CRN: 
CAW: 
 » show all
Taxonomy
Reference
1  [PMID:11741920]
  Authors
Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA.
  Title
A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy.
  Journal
J. Biol. Chem. 277 (2002) 3069-72.
  Sequence
[pde:Pden_0015]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
425642-27-9

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