KEGG   ENZYME: 4.4.1.22Help
Entry
EC 4.4.1.22                 Enzyme                                 

Name
S-(hydroxymethyl)glutathione synthase;
glutathione-dependent formaldehyde-activating enzyme;
Gfa;
S-(hydroxymethyl)glutathione formaldehyde-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)
Reaction(IUBMB)
S-(hydroxymethyl)glutathione = glutathione + formaldehyde [RN:R06982]
Reaction(KEGG)
Substrate
S-(hydroxymethyl)glutathione [CPD:C14180]
Product
glutathione [CPD:C00051];
formaldehyde [CPD:C00067]
Comment
The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.
History
EC 4.4.1.22 created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 4.4.1.22)
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K03396  S-(hydroxymethyl)glutathione synthase
Genes
PHD: 102339062
SMP: SMAC_08712
PAN: PODANSg505
TTT: THITE_49799
TMN: UCRPA7_692
FGR: FGSG_10776
FPU: FPSE_08822
FVR: FVEG_11444
FOX: FOXG_12705
NHE: NECHADRAFT_69107
MAJ: MAA_09901
ANG: ANI_1_14024(An02g00080)
PTE: PTT_17259
XCC: XCC3388
XCB: XC_0776
XCA: xcc-b100_0811(gfa)
XCP: XCR_3724(gfa)
XCV: XCV0789
XAX: XACM_0733
XAC: XAC0735
XOM: XOO3646(XOO3646)
XOP: PXO_04414
XPH: XppCFBP6546_16605(XppCFBP6546P_16605)
DKO: I596_2122
VFI: VF_A0007
VFM: VFMJ11_A0021(gfa)
VSA: VSAL_II0213(gfa)
PPR: PBPRB1570
PCQ: PcP3B5_24880(gfa)
PPX: T1E_5519
PSB: Psyr_2957
PPUU: PputUW4_02203(gfa)
PKC: PKB_4293(gfa)
SSE: Ssed_4230
SWD: Swoo_0373
SVO: SVI_3944(gfa)
MVS: MVIS_3174(gfa)
BAM: Bamb_5797
AMIM: MIM_c14300(gfa)
VEI: Veis_4024
MMS: mma_2819
MLO: mlr0874
SME: SM_b20186
SMI: BN406_06470(gfa)
SMEL: SM2011_b20186(gfa)
SMER: DU99_32400
SMD: Smed_3930
RHI: NGR_b14630(gfa1) NGR_c19300 NGR_c20490(gfa2)
SAME: SAMCFNEI73_Ch0088(gfa)
EAD: OV14_a1033(gfa2)
REL: REMIM1_PF00508(gfa)
REI: IE4771_PD00410(gfa)
REP: IE4803_PC00392(gfa)
RLE: pRL120526(gfA)
RLG: Rleg_4832
RHL: LPU83_2360(gfa)
RGA: RGR602_PC00929(gfa-1) RGR602_PC02286(gfa-2)
RHN: AMJ98_PE00477(gfa)
RPHA: AMC79_PD00607(gfa)
RHT: NT26_3258(gfa)
RHX: AMK02_PD00340(gfa)
SHZ: shn_31780
BJA: blr6216
BRA: BRADO5487(gfa)
BBT: BBta_5971(gfa)
BRS: S23_20790
AOL: S58_22210
BRO: BRAD285_1746(gfa)
BRK: CWS35_16195(gfa) CWS35_32580(gfa)
RPC: RPC_0100
RPE: RPE_4679
RSP: RSP_2575
PDE: Pden_0015
PYE: A6J80_09895(gfa)
PZH: CX676_13675(gfa)
PARO: CUV01_07510(gfa)
SAGU: CDO87_25880(gfa)
ACR: Acry_2793
AMV: ACMV_31250(gfa)
MAGQ: MGMAQ_0499(gfa)
AFR: AFE_0696(gfa)
SIV: SSIL_2807
CRN: CAR_c23670(gfa)
 » show all
Taxonomy
Reference
1  [PMID:11741920]
  Authors
Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA.
  Title
A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy.
  Journal
J. Biol. Chem. 277 (2002) 3069-72.
  Sequence
[pde:Pden_0015]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.22
IUBMB Enzyme Nomenclature: 4.4.1.22
ExPASy - ENZYME nomenclature database: 4.4.1.22
UM-BBD (Biocatalysis/Biodegradation Database): 4.4.1.22
BRENDA, the Enzyme Database: 4.4.1.22
CAS: 425642-27-9

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