KEGG   ENZYME: 4.4.1.9Help
Entry
EC 4.4.1.9                  Enzyme                                 

Name
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
Reaction(IUBMB)
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]
Reaction(KEGG)
R03524;
(other) R02846
Show
Substrate
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]
Product
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]
Comment
Contains pyridoxal phospate.
History
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13034  L-3-cyanoalanine synthase/ cysteine synthase
Genes
RSS: 109441616
ATH: AT3G61440(CYSC1)
ALY: ARALYDRAFT_342794(ATCYSC1) ARALYDRAFT_486620(ATCYSC1)
CRB: 17886219
CSAT: 104699755 104747140 104749184 104788433
EUS: EUTSA_v10006044mg
BRP: 103841966 103862824
BNA: 106393304 106396803 106415606 106415702 106415710 106444997
BOE: 106311835 106336914 106338498
THJ: 104802038 104817302
CPAP: 110820910
CIT: 102609716
TCC: 18614120
DZI: 111304748
EGR: 104443429
GMX: 100101899(OAS-TL3) 100806420
VRA: 106759445
VAR: 108329722
CCAJ: 109802499
CAM: 101512608
LJA: Lj1g3v2682510.1(Lj1g3v2682510.1)
FVE: 101292050
PPER: 18786519
PMUM: 103342779
PAVI: 110751794
MDM: 103401891(CAS1) 103405317(CAS2) 103406176
ZJU: 107404050
CSV: 101220896
CMO: 103497706
MCHA: 111024353
CMAX: 111499275
CMOS: 111460401
CPEP: 111807524
JCU: 105642966
JRE: 109021531
VVI: 100255091
SOT: 102601315(PCAS-2) 102604154(PCAS-1)
CANN: 107839203
SIND: 105172766
OEU: 111390009
LSV: 111902665
DCR: 108210215
BVG: 104887240
SOE: 110789773
NNU: 104610634
OSA: 4335048
DOSA: Os04t0165700-01(Os04g0165700)
OBR: 102715851
BDI: 100835065
ATS: 109731680(LOC109731680)
SBI: 8066013
ZMA: 100216722
SITA: 101779131
PDA: 103715474
EGU: 105043037
MUS: 103985756
DCT: 110097663
AOF: 109837549
ATR: 18422839
 » show all
Taxonomy
Reference
1  [PMID:1055433]
  Authors
Akopyan TN, Braunstein AE, Goryachenkova EV.
  Title
Beta-cyanoalanine synthase: purification and characterization.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 1617-21.
Reference
2  [PMID:5001194]
  Authors
Castric PA, Conn EE.
  Title
Formation of  -cyanoalanine by O-acetylserine sulfhydrylase.
  Journal
J. Bacteriol. 108 (1971) 132-6.
Reference
3
  Authors
Hendrickson, H.R.
  Title
The beta-cyanoalanine synthase of blue lupine.
  Journal
Fed. Proc. 27 (1968) 593.
Reference
4  [PMID:5769995]
  Authors
Hendrickson HR, Conn EE.
  Title
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
  Journal
J. Biol. Chem. 244 (1969) 2632-40.
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.9
IUBMB Enzyme Nomenclature: 4.4.1.9
ExPASy - ENZYME nomenclature database: 4.4.1.9
BRENDA, the Enzyme Database: 4.4.1.9
CAS: 9059-53-4

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