KEGG   ENZYME: 4.4.1.9Help
Entry
EC 4.4.1.9                  Enzyme                                 

Name
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
Reaction(IUBMB)
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]
Reaction(KEGG)
R03524;
(other) R02846
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Substrate
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]
Product
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]
Comment
Contains pyridoxal phospate.
History
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
Pathway
Cyanoamino acid metabolism
Metabolic pathways
Orthology
K13034  
L-3-cyanoalanine synthase/ cysteine synthase
Genes
ATH: 
AT3G61440(CYSC1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0002s16220g(POPTRDRAFT_552184) POPTR_0014s08210g(POPTRDRAFT_244580)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0165700-01(Os04g0165700)
OBR: 
BDI: 
SBI: 
SORBI_06g001610(SORBIDRAFT_06g001610)
ZMA: 
SITA: 
ATR: 
s00009p00219590(AMTR_s00009p00219590)
 » show all
Taxonomy
Reference
1  [PMID:1055433]
  Authors
Akopyan TN, Braunstein AE, Goryachenkova EV.
  Title
Beta-cyanoalanine synthase: purification and characterization.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 1617-21.
Reference
2  [PMID:5001194]
  Authors
Castric PA, Conn EE.
  Title
Formation of  -cyanoalanine by O-acetylserine sulfhydrylase.
  Journal
J. Bacteriol. 108 (1971) 132-6.
Reference
3
  Authors
Hendrickson, H.R.
  Title
The beta-cyanoalanine synthase of blue lupine.
  Journal
Fed. Proc. 27 (1968) 593.
Reference
4  [PMID:5769995]
  Authors
Hendrickson HR, Conn EE.
  Title
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
  Journal
J. Biol. Chem. 244 (1969) 2632-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-53-4

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