KEGG   ENZYME: 4.5.1.2Help
Entry
EC 4.5.1.2                  Enzyme                                 

Name
3-chloro-D-alanine dehydrochlorinase;
beta-chloro-D-alanine dehydrochlorinase;
3-chloro-D-alanine chloride-lyase (deaminating)
Class
Lyases;
Carbon-halide lyases;
Carbon-halide lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
3-chloro-D-alanine + H2O = pyruvate + chloride + NH3 [RN:R01031]
Reaction(KEGG)
Substrate
3-chloro-D-alanine [CPD:C02634];
H2O [CPD:C00001]
Product
pyruvate [CPD:C00022];
chloride [CPD:C00698];
NH3 [CPD:C00014]
Comment
A pyridoxal-phosphate protein. Also catalyses beta-replacement reactions, e.g. converts 3-chloro-D-alanine and H2S into D-cysteine and HCl.
History
EC 4.5.1.2 created 1984
Reference
1  [PMID:3132906]
  Authors
Nagasawa T, Ishii T, Yamada H.
  Title
Physiological comparison of D-cysteine desulfhydrase of Escherichia coli with 3-chloro-D-alanine dehydrochlorinase of Pseudomonas putida CR 1-1.
  Journal
Arch. Microbiol. 149 (1988) 413-6.
  Organism
Escherichia coli, Pseudomonas putida
Reference
2  [PMID:6791643]
  Authors
Yamada H, Nagasawa T, Ohkishi H, Kawakami B, Tani Y.
  Title
Synthesis of D-cysteine from 3-chloro-D-alanine and hydrogen sulfide by 3-chloro-D-alanine hydrogen chloride-lyase (deaminating) of Pseudomonas putida.
  Journal
Biochem. Biophys. Res. Commun. 100 (1981) 1104-10.
  Organism
Pseudomonas putida
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
78990-65-5

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