KEGG   ENZYME: 4.6.1.2Help
Entry
EC 4.6.1.2                  Enzyme                                 

Name
guanylate cyclase;
guanylyl cyclase;
guanyl cyclase;
GTP diphosphate-lyase (cyclizing)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Reaction(IUBMB)
GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Reaction(KEGG)
Substrate
GTP [CPD:C00044]
Product
3',5'-cyclic GMP [CPD:C00942];
diphosphate [CPD:C00013]
Comment
Also acts on ITP and dGTP.
History
EC 4.6.1.2 created 1972
Pathway
Purine metabolism
Orthology
K01769  
guanylate cyclase, other
K12318  
guanylate cyclase soluble subunit alpha
K12319  
guanylate cyclase soluble subunit beta
K12320  
heat-stable enterotoxin receptor
K12321  
guanylate cyclase 2D/E/F
K12323  
atrial natriuretic peptide receptor A
K12324  
atrial natriuretic peptide receptor B
Genes
HSA: 
2977(GUCY1A2) 2982(GUCY1A3) 2983(GUCY1B3) 2984(GUCY2C) 2986(GUCY2F) 3000(GUCY2D) 4881(NPR1) 4882(NPR2)
PTR: 
100608597(GUCY1A3) 452727(GUCY1B2) 457329(NPR1) 461565(GUCY1B3) 465084(NPR2) 465806(GUCY2F) 466769(GUCY1A2) 473375(GUCY2C) 750641(GUCY2D)
PPS: 
100975209(GUCY2C) 100976525(GUCY2D) 100980358 100983770(NPR1) 100984343(GUCY2F) 100984704(GUCY1B3) 100985928(GUCY1A3) 100987635(GUCY1A2) 100991030(NPR2)
GGO: 
101128425 101134962(GUCY2F) 101139175(GUCY1A3) 101140749(GUCY2D) 101141380(GUCY1B3) 101145840(NPR2) 101146114
PON: 
100172608(GUCY1A3) 100434873(GUCY1B3) 100437411(NPR2) 100442459 100443214(GUCY2D) 100445008 100445361(GUCY1A2) 100451211(GUCY2F) 100460918(GUCY2C)
MCC: 
100424944(GUCY1B3) 695750(NPR2) 699191(GUCY2C) 699365(GUCY1A3) 704485(GUCY2F) 706615(GUCY1A2) 715598(NPR1) 716734(GUCY2D)
MCF: 
MMU: 
14917(Gucy2c) 14918(Gucy2d) 14919(Gucy2e) 18160(Npr1) 230103(Npr2) 234889(Gucy1a2) 239134(Gucy1b2) 245650(Gucy2f) 54195(Gucy1b3) 60596(Gucy1a3)
RNO: 
113911(Gucy2d) 116556(Gucy2f) 116564(Npr2) 24603(Npr1) 25202(Gucy1b3) 25206(Gucy1b2) 25711(Gucy2c) 497757(Gucy1a3) 66012(Gucy1a2) 79222(Gucy2e)
CGE: 
HGL: 
101697777 101702803(Gucy1a2) 101707903(Gucy2f) 101712380(Npr2) 101712487(Gucy1a3) 101714641(Npr1) 101717731 101720874(Gucy2c) 101724888(Gucy1b3) 101726611
TUP: 
102469297(GUCY1A2) 102482734(NPR1) 102483882(GUCY1A3) 102485635 102488370(GUCY1B3) 102494681 102495739(GUCY2C) 102496410(GUCY2D) 102502023(NPR2)
CFA: 
403863(GUCY2D) 474762(NPR2) 479455(GUCY1A2) 481016(GUCY2F) 482663(GUCY1A3) 485179 485435 486671(GUCY2C) 490455(NPR1) 553102(GUCY1B3)
AML: 
FCA: 
101080682(NPR1) 101089435(GUCY1B3) 101090242(GUCY2F) 101094301(NPR2) 101095109(GUCY2C) 101098377(GUCY1A3) 101098598 101099494(GUCY1A2) 101099582 101101009
PTG: 
102949070(NPR2) 102949926(GUCY2F) 102955254(NPR1) 102956040 102963095(GUCY2C) 102963951(GUCY1B3) 102969669(GUCY1A3) 102970885 102971963
BTA: 
100295021(GUCY2E) 281216(GUCY1A3) 281357(NPR2) 282244(GUCY2C) 282245(GUCY2D) 282246(GUCY2F) 282433(GUCY1B3) 533048(NPR1) 613600(GUCY1A2)
BOM: 
PHD: 
102316801(NPR2) 102319851(GUCY2F) 102325669 102326726(GUCY2D) 102328814(GUCY1A2) 102329923(NPR1) 102332578(GUCY1B3) 102341269 102341664(GUCY2C) 102343775
CHX: 
100861577(NPR2) 102169406(GUCY1B3) 102169418(GUCY2D) 102169692 102176347 102180380(GUCY2F) 102182418 102184168(GUCY1A2) 102186447(NPR1)
SSC: 
100153508(NPR1) 100512698(NPR2) 100522091(GUCY1A2) 100523457 100625149 100625536 397193(GUCY2C) 444999(GUCY1B3) 553100(GUCY1A3)
CFR: 
102503713(GUCY2D) 102507709(NPR2) 102508002(GUCY1A3) 102508234(GUCY1B3) 102509037 102510749 102514869(NPR1) 102516411(GUCY2C) 102522209 102523651(GUCY1A2)
ECB: 
100054420 100054502(GUCY2F) 100055416(NPR2) 100061959(NPR1) 100063810(GUCY2C) 100069474(GUCY1A2) 100069551(GUCY1B3) 100069573(GUCY1A3) 100073037(GUCY2D)
MYB: 
102238967(NPR2) 102241126(GUCY2F) 102242149 102243506(GUCY2D) 102247939(GUCY2C) 102249825(NPR1) 102250379(GUCY1B3) 102250686(GUCY1A3) 102260196(GUCY1A2) 102261219
MYD: 
102751706(GUCY2D) 102755806(NPR1) 102758657 102760543 102764771(GUCY1A3) 102767033(GUCY1A2) 102769452(GUCY1B3) 102771508(NPR2) 102772626(GUCY2C)
PALE: 
102878600(GUCY2F) 102879793(NPR1) 102883474(GUCY2C) 102884807 102885265(NPR2) 102889391 102889502(GUCY1A3) 102889920(GUCY1B3) 102892708(GUCY2D) 102896673(GUCY1A2)
MDO: 
SHR: 
100921433 100921526(NPR1) 100925538(GUCY2C) 100928661(GUCY1A3) 100929308(GUCY1A2) 100931427(GUCY1B3) 100932093 100932257 100932333(NPR2)
OAA: 
GGA: 
100859339(NPR2) 417968(GUCY2C) 419089(GUCY2F) 422407(GUCY1A3) 422408(GUCY1B3) 429128(GUCY1B2) 771678(GUCY1A2)
MGP: 
TGU: 
100217644(GUCY1A2) 100223544(GUCY1B3) 100223563(GUCY1A3) 100225337 100227153(NPR2) 100228246(GUCY2C) 100229764
FAB: 
101807229(NPR2) 101812872(GUCY1A2) 101814320(GUCY1A3) 101815504(GUCY1B3) 101816039(GUCY2C) 101816994 101818523
PHI: 
102099657 102105071 102105257(NPR2) 102106220(GUCY1A3) 102106413(GUCY1B3) 102111535(GUCY2C) 102113474(GUCY1A2) 102114027(GUCY2D)
APLA: 
FPG: 
101913205(GUCY2C) 101914436(GUCY1A2) 101915374(GUCY1B3) 101916520 101916740(NPR2) 101920979 101922339(GUCY1A3) 101924821
FCH: 
102046999(GUCY1A3) 102048540(GUCY1B3) 102050145 102050949(NPR1) 102051925(NPR2) 102053014(GUCY2C) 102054518 102055553 102059430(GUCY1A2)
CLV: 
102086091 102090855(GUCY1A3) 102091284 102091873(GUCY1B3) 102095707 102097001(NPR1) 102097143(GUCY1A2) 102098846(NPR2) 102098904(GUCY2C)
ASN: 
PSS: 
102444148(GUCY2C) 102444454(GUCY1A2) 102446826(GUCY1A3) 102447071(GUCY1B3) 102451086(GUCY2D) 102451605 102452749
CMY: 
102931425 102933143(NPR2) 102934622(GUCY1A2) 102938442(GUCY1A3) 102938663(GUCY1B3) 102945517(NPR1) 102946484 102947911(GUCY2C) 102948195
ACS: 
XLA: 
378662(gucy2c) 399070(npr1) 399350(npr2) 432281(gucy1b3)
XTR: 
100145454(gucy1a2) 100379900(gucy1b3) 100486678(gucy2c) 100488543(npr2) 100489435 100492092 100492820(gucy2f) 100496590(gucy2d) 100496677(gucy1a3) 100496697
DRE: 
100150304(gucy1b3) 140424(gucy2f) 140425(gc2) 550420(gucy1a3) 557191 560653(npr1a) 568219 572052
TRU: 
MZE: 
OLA: 
100049177(gucy1a3) 100049178(gucy1b3) 100049183(npr2) 100049189(olgc-r1) 100049248(olgcs-alpha2) 100125799(olgc2) 100125818(olgc9) 100125819(olgc7) 100216004(olgc-r2)
XMA: 
LCM: 
102346928(GUCY2C) 102349899 102357917(NPR1) 102358088 102361913(GUCY1B3) 102362175(GUCY1A3) 102366428(GUCY2F)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408879(sGC-alpha1) 408880(Gycbeta1) 724571(GB10108) 726069
NVI: 
TCA: 
BMOR: 
100642185(GC-a1) 100862777(GC-b1) 101739209 692412(Gcy)
API: 
PHU: 
ISC: 
CEL: 
CELE_AH6.1(gcy-1) CELE_C46E1.2(gcy-36) CELE_C49H3.1(gcy-8) CELE_F08B1.2(gcy-12) CELE_F21H7.9(gcy-20) CELE_F22E5.3(gcy-21) CELE_M04G12.3(gcy-34) CELE_R134.1(gcy-3) CELE_R134.2(gcy-2) CELE_T01A4.1(gcy-28) CELE_T04D3.4(gcy-35) CELE_T26C12.4(gcy-23) CELE_W03F11.2(gcy-17) CELE_ZC239.7(gcy-15) CELE_ZC412.2(gcy-14) CELE_ZK896.8(gcy-18) CELE_ZK970.6(gcy-5)
CBR: 
CBG03898 CBG07710 CBG14865(Cbr-gcy-28) CBG20390(Cbr-gcy-35)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
MBR: 
ACAN: 
PFA: 
PYO: 
PKN: 
TAN: 
TPS: 
TVA: 
PAT: 
MFA: 
MMB: 
MEH: 
BRA: 
BBT: 
JAN: 
MGI: 
TER: 
 » show all
Taxonomy
Reference
1  [PMID:235291]
  Authors
Garbers DL, Suddath JL, Hardman JG.
  Title
Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity.
  Journal
Biochim. Biophys. Acta. 377 (1975) 174-85.
  Organism
Rattus norvegicus, sea urchin
Reference
2  [PMID:4982201]
  Authors
Hardman JG, Sutherland EW.
  Title
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate.
  Journal
J. Biol. Chem. 244 (1969) 6363-70.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-75-5

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