KEGG   ENZYME: 5.1.1.17Help
Entry
EC 5.1.1.17                 Enzyme                                 

Name
isopenicillin-N epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
penicillin-N 5-amino-5-carboxypentanoyl-epimerase
Reaction(IUBMB)
isopenicillin N = penicillin N [RN:R04147]
Reaction(KEGG)
Substrate
isopenicillin N [CPD:C05557]
Product
penicillin N [CPD:C06564]
Comment
This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here).
History
EC 5.1.1.17 created 2002
Pathway
Penicillin and cephalosporin biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Orthology
K04127  
isopenicillin-N epimerase
Genes
XCC: 
XCC1212(nifS)
XCB: 
XCA: 
XCP: 
XAX: 
XPE: 
RSO: 
RSC: 
RSL: 
RSN: 
RSM: 
RSE: 
BMA: 
BML: 
BMN: 
BMAL: 
BMAE: 
BMAQ: 
BMAI: 
BMAF: 
BMAZ: 
BMAB: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPSM: 
BPSU: 
BPSD: 
BPZ: 
BPQ: 
BPK: 
BPSH: 
BPSA: 
BPSO: 
BUT: 
BTD: 
BUL: 
BUD: 
RGE: 
RBN: 
MXA: 
MXAN_5758(cefD)
MSD: 
MYM: 
CCX: 
SUR: 
AGE: 
MBD: 
CFUS: 
SCL: 
SCU: 
CCRO: 
SAMY: 
MRM: 
BBA: 
BBAT: 
BBW: 
BBAC: 
DEQ: 
MEY: 
CBOT: 
SGB: 
SVL: 
SCT: 
SCAT_5686(cefD)
SCY: 
SBH: 
SRC: 
STRM: 
SCX: 
STRF: 
STRT: 
SCLF: 
SAUO: 
KSK: 
KAU: 
MIM: 
MIX: 
MIP: 
MICR: 
MVD: 
ARM: 
AAQ: 
ARW: 
ICA: 
TEZ: 
KFL: 
KRA: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACPL_7270(cefD)
ACTN: 
L083_6863(cefD)
AFS: 
PLK: 
CAI: 
MCU: 
BLN: 
BLON: 
BBV: 
BBRE: 
BBRV: 
BBRC: 
BBRN: 
BBRD: 
BSCA: 
CYA: 
CYA_0818(cefD)
CYB: 
CYB_1874(cefD)
LEN: 
LET: 
LBO: 
PSEU: 
MAR: 
MPK: 
CYC: 
CYN: 
CYJ: 
MIC: 
GEI: 
OAC: 
ONI: 
NOS: 
NOP: 
CALT: 
CALH: 
PLP: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
ATM: 
CAP: 
MRB: 
MRE: 
RBA: 
RB7564(cefD)
PIR: 
PLM: 
PBS: 
PLS: 
FMR: 
GES: 
IPA: 
ABAC: 
LuPra_04390(cefD_4)
FBR: 
FTE: 
FLU: 
 » show all
Taxonomy
Reference
1  [PMID:2804141]
  Authors
Usui S, Yu CA.
  Title
Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus.
  Journal
Biochim. Biophys. Acta. 999 (1989) 78-85.
  Sequence
Reference
2
  Authors
Laiz, L., Liras, P., Castro, J.M. and Martin, J.F.
  Title
Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans.
  Journal
J. Gen. Microbiol. 136 (1990) 663-671.
Reference
3  [PMID:1354366]
  Authors
Cantwell C, Beckmann R, Whiteman P, Queener SW, Abraham EP.
  Title
Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway.
  Journal
Proc. R. Soc. Lond. B. Biol. Sci. 248 (1992) 283-9.
Reference
4
  Authors
Yeh, W.K., Ghag, S.K. and Queener, S.W.
  Title
Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3'-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering.
  Journal
Ann. N.Y. Acad. Sci. 672 (1992) 396-408.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
88201-43-8

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