KEGG   ENZYME: 5.1.1.18Help
Entry
EC 5.1.1.18                 Enzyme                                 

Name
serine racemase;
SRR
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
serine racemase
Reaction(IUBMB)
L-serine = D-serine [RN:R00589]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065]
Product
D-serine [CPD:C00740]
Comment
A pyridoxal-phosphate protein that is highly selective for L-serine as substrate. D-Serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors [1,2]. The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations [4].
History
EC 5.1.1.18 created 2007
Pathway
Glycine, serine and threonine metabolism
Orthology
K12235  
serine racemase
K18348  
serine/alanine racemase
Genes
HSA: 
63826(SRR)
PTR: 
747543(SRR)
PPS: 
GGO: 
PON: 
MCC: 
703426(SRR)
MCF: 
MMU: 
27364(Srr)
RNO: 
303306(Srr)
CGE: 
HGL: 
TUP: 
AML: 
FCA: 
PTG: 
BTA: 
525340(SRR)
BOM: 
PHD: 
CHX: 
BACU: 
LVE: 
ECB: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
771635(SRR)
MGP: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
PSS: 
CMY: 
XTR: 
LCM: 
BFO: 
CIN: 
SPU: 
BMY: 
NVE: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0001s09190g(POPTRDRAFT_548481)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0555900-01(Os04g0555900)
OBR: 
BDI: 
ZMA: 
SITA: 
ATR: 
s00009p00255960(AMTR_s00009p00255960)
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
MPP: 
CSL: 
CVR: 
CCP: 
MBR: 
DDI: 
ACAN: 
PTI: 
PIF: 
EHX: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
BBE: 
ECAS: 
CLB: 
RBR: 
CLE: 
CSO: 
CAD: 
CDF: 
CDC: 
CD196_1551(vanTG)
CDL: 
CDG: 
DGI: 
OVA: 
 » show all
Taxonomy
Reference
1  [PMID:10557334]
  Authors
Wolosker H, Blackshaw S, Snyder SH.
  Title
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13409-14.
  Organism
Mus musculus
  Sequence
[mmu:27364]
Reference
2  [PMID:9892700]
  Authors
Wolosker H, Sheth KN, Takahashi M, Mothet JP, Brady RO Jr, Ferris CD, Snyder SH.
  Title
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 721-5.
Reference
3  [PMID:11054547]
  Authors
De Miranda J, Santoro A, Engelender S, Wolosker H.
  Title
Human serine racemase: moleular cloning, genomic organization and functional analysis.
  Journal
Gene. 256 (2000) 183-8.
  Organism
Homo sapiens
  Sequence
[hsa:63826]
Reference
4  [PMID:15536068]
  Authors
Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, Shleper M, Li P, Toney MD, Kartvelishvily E, Wolosker H.
  Title
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity.
  Journal
J. Biol. Chem. 280 (2005) 1754-63.
  Organism
Mus musculus
  Sequence
[mmu:27364]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77114-08-0

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