KEGG   ENZYME: 5.1.1.19Help
Entry
EC 5.1.1.19                 Enzyme                                 

Name
O-ureido-serine racemase;
dcsC (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
Reaction(IUBMB)
O-ureido-L-serine = O-ureido-D-serine [RN:R10488]
Reaction(KEGG)
Substrate
O-ureido-L-serine [CPD:C20639]
Product
O-ureido-D-serine [CPD:C20651]
Comment
The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
History
EC 5.1.1.19 created 2013
Pathway
Biosynthesis of antibiotics
Orthology
K19724  
O-ureido-serine racemase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for  the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob. Agents. Chemother. 54 (2010) 1132-9.
  Sequence
Reference
2  [PMID:22307920]
  Authors
Dietrich D, van Belkum MJ, Vederas JC
  Title
Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine.
  Journal
Org. Biomol. Chem. 10 (2012) 2248-54.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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