KEGG   ENZYME: 5.1.3.23Help
Entry
EC 5.1.3.23                 Enzyme                                 

Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase;
UDP-GlcNAc3NAcA 2-epimerase;
UDP-alpha-D-GlcNAc3NAcA 2-epimerase;
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase;
WbpI;
WlbD
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [RN:R09600]
Reaction(KEGG)
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Product
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [CPD:C19745]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].
History
EC 5.1.3.23 created 2007
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K13019  
UDP-GlcNAc3NAcA epimerase
Genes
PLU: 
plu4804(wblH)
PAY: 
PAU_04319(wblH)
PTT: 
PAE: 
PA3148(wbpI)
PAEV: 
PAEI: 
PAEC: 
PAEO: 
PDR: 
PSES: 
SSE: 
MARI: 
AAUS: 
LAL: 
CEY: 
TNI: 
TVNIR_0699(wecB_[C])
TTI: 
MMW: 
TOR: 
LHK: 
PPNO: 
BPE: 
BP0090(bplD)
BPC: 
BPTD_0086(bplD)
BPER: 
BPET: 
BPEU: 
Q425_2030(bplD)
BPA: 
BPP0152(bplD)
BPAR: 
BBR: 
BB0152(bplD)
BBM: 
BBH: 
BBX: 
BPT: 
Bpet4819(wlbD)
BHO: 
BHM: 
BHZ: 
BTRM: 
TEQ: 
TEA: 
TEG: 
AAV: 
ACK: 
MASW: 
HMS: 
HBI: 
WSU: 
WS2189(WBPI)
TDN: 
CCO: 
ABU: 
GLO: 
GSB: 
DDN: 
DSF: 
DOL: 
DAO: 
EAA: 
HNI: 
HBC: 
MAI: 
MAN: 
BACI: 
BMET: 
BON: 
GKA: 
GTE: 
GYC: 
GYA: 
GCT: 
GGH: 
GEL: 
GSE: 
LAO: 
POD: 
PNP: 
CBO: 
CBA: 
CBH: 
CBY: 
CBL: 
CBK: 
CBB: 
CBI: 
CBT: 
CBF: 
CBM: 
CBJ: 
CBE: 
CBZ: 
CKL: 
CKR: 
CLJ: 
CCB: 
CSR: 
CSB: 
CAH: 
CSQ: 
CLD: 
CCK: 
CBUT: 
CTYK: 
CCEL: 
DKU: 
DOR: 
DAI: 
DMI: 
ELM: 
SAY: 
TPY_3671(wecB)
SAP: 
TTE: 
TTE0661(WecB2)
MAS: 
GLP: 
GEI: 
GLJ: 
GKIL_0481(wecB)
CALH: 
RRS: 
RCA: 
CAG: 
CAP: 
DSW: 
TTH: 
PUV: 
TPED: 
TRM: 
TPX: 
GMA: 
TRS: 
TLI: 
AMO: 
PBS: 
BACC: 
PPN: 
TFO: 
OSP: 
DOI: 
RMG: 
CPI: 
ZGA: 
TDI: 
LUT: 
FTE: 
OHO: 
BBAU: 
MRO: 
CNI: 
DTH: 
DTU: 
 » show all
Taxonomy
Reference
1  [PMID:17346239]
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem. J. 405 (2007) 123-30.
  Sequence
[pae:PA3148] [bpe:BP0090]
Reference
2
  Authors
Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S.
  Title
Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem. J. 405 (2007) 625.
Reference
3  [PMID:11526328]
  Authors
Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH.
  Title
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 57 (2001) 1310-2.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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