KEGG   ENZYME: 5.1.3.27Help
Entry
EC 5.1.3.27                 Enzyme                                 

Name
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase;
dTDP-deoxyglucose 3-epimerase;
dTDP-4-keto-6-deoxy-D-glucose 3-epimerase;
dTDP-4-keto-6-deoxyglucose 3-epimerase;
gerF (gene name);
tylJ (gene name);
chmJ (gene name);
mydH (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3-epimerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-gulose [RN:R06437]
Reaction(KEGG)
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-gulose [CPD:C11926]
Comment
The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
History
EC 5.1.3.27 created 2013
Pathway
Polyketide sugar unit biosynthesis
Biosynthesis of antibiotics
Orthology
K13312  
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
K19855  
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
Genes
STRM: 
Taxonomy
Reference
1  [PMID:15049360]
  Authors
Sohng JK, Kim HJ, Nam DH, Lim DO, Han JM, Lee HJ, Yoo JC
  Title
Cloning, expression, and biological function of a dTDP-deoxyglucose epimerase (gerF) gene from Streptomyces sp. GERI-155.
  Journal
Biotechnol. Lett. 26 (2004) 185-91.
  Sequence
Reference
2  [PMID:17053005]
  Authors
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
  Title
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
  Journal
Glycobiology. 17 (2007) 119-26.
  Sequence
Reference
3  [PMID:23116432]
  Authors
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
  Title
Structural and functional studies on a 3'-epimerase involved in the biosynthesis  of dTDP-6-deoxy-D-allose.
  Journal
Biochemistry. 51 (2012) 9375-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system