KEGG   ENZYME: 5.1.3.33Help
Entry
EC 5.1.3.33                 Enzyme                                 

Name
2-epi-5-epi-valiolone epimerase;
CetB;
EVE
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2-epi-5-epi-valiolone 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone = 5-epi-valiolone [RN:R11079]
Reaction(KEGG)
Substrate
2-epi-5-epi-valiolone [CPD:C17691]
Product
5-epi-valiolone [CPD:C17694]
Comment
The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.
History
EC 5.1.3.33 created 2015
Pathway
Acarbose and validamycin biosynthesis
Biosynthesis of antibiotics
Orthology
K20431  
2-epi-5-epi-valiolone epimerase
Genes
KOR: 
LAZ: 
DDD: 
PAO: 
RHD: 
VNI: 
PBM: 
SWD: 
CPS: 
PIN: 
MARS: 
GBI: 
PSE: 
AZO: 
MLO: 
MCI: 
MOP: 
MAM: 
HOE: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
EAH: 
REP: 
RTR: 
BRA: 
BBT: 
AOL: 
XAU: 
BNE: 
MALG: 
NRE: 
SPHI: 
SSAN: 
SCH: 
BLAS: 
BPUM: 
MGO: 
GTA: 
SHY: 
SHO: 
SRC: 
SCZ: 
SLE: 
sle_45900(sle_45900)
MIO: 
ARR: 
ARH: 
ACH: 
GAR: 
NCA: 
PSIM: 
FAL: 
NML: 
BSD: 
AJA: 
 » show all
Taxonomy
Reference
1  [PMID:19101977]
  Authors
Wu X, Flatt PM, Xu H, Mahmud T.
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem. 10 (2009) 304-14.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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