KEGG   ENZYME: 5.1.3.33Help
Entry
EC 5.1.3.33                 Enzyme                                 

Name
2-epi-5-epi-valiolone epimerase;
CetB;
EVE
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2-epi-5-epi-valiolone 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone = 5-epi-valiolone [RN:R11079]
Reaction(KEGG)
Substrate
2-epi-5-epi-valiolone [CPD:C17691]
Product
5-epi-valiolone [CPD:C17694]
Comment
The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.
History
EC 5.1.3.33 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20431  2-epi-5-epi-valiolone epimerase
Genes
KOR: AWR26_18685
LAZ: A8A57_10045
DDD: Dda3937_02324
PAO: Pat9b_4679
TCI: A7K98_11835
RHD: R2APBS1_1766
VOW: A9237_16025
VNI: VIBNI_B0417
VBR: A6E01_18210
PBM: CL52_14240
SWD: Swoo_2939
CPS: CPS_3057
PIN: Ping_2781
HBE: BEI_1474(cetB)
PSE: NH8B_2457
AZO: azo3874
AOA: dqs_4018
TCL: Tchl_1480
MLO: mll5435
SMER: DU99_22100
BRA: BRADO0888
BBT: BBta_7167
AOL: S58_67440
XAU: Xaut_1570
MALG: MALG_03368
SPHI: TS85_07460
SSAN: NX02_18210
SPKC: KC8_08375
BLAS: BSY18_670
BPUM: BW16_09470
BPUS: UP12_08840
SHY: SHJG_0279
SLE: sle_45900(sle_45900)
ACH: Achl_3699
NCA: Noca_4455
PSIM: KR76_25415
FAL: FRAAL4638
NML: Namu_2113
FLN: FLA_2939
 » show all
Taxonomy
Reference
1  [PMID:19101977]
  Authors
Wu X, Flatt PM, Xu H, Mahmud T.
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem. 10 (2009) 304-14.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.33
IUBMB Enzyme Nomenclature: 5.1.3.33
ExPASy - ENZYME nomenclature database: 5.1.3.33
BRENDA, the Enzyme Database: 5.1.3.33

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