KEGG   ENZYME: 5.1.3.35Help
Entry
EC 5.1.3.35                 Enzyme                                 

Name
2-epi-5-epi-valiolone 7-phosphate 2-epimerase;
AcbO
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate [RN:R11081]
Reaction(KEGG)
Substrate
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Product
5-epi-valiolone 7-phosphate [CPD:C17693]
Comment
The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
History
EC 5.1.3.35 created 2015
Pathway
Acarbose and validamycin biosynthesis
Biosynthesis of antibiotics
Orthology
K19974  
2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Genes
SERR: 
HAS: 
MUL: 
MMI: 
SALS: 
SVT: 
SCZ: 
SRW: 
ASE: 
ACPL_3679(acbO)
Taxonomy
Reference
1  [PMID:12681481]
  Authors
Zhang CS, Podeschwa M, Altenbach HJ, Piepersberg W, Wehmeier UF
  Title
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
  Journal
FEBS. Lett. 540 (2003) 47-52.
  Sequence
[ase:ACPL_3679]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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