KEGG   ENZYME: 5.1.3.36Help
Entry
EC 5.1.3.36                 Enzyme                                 

Name
heparosan-glucuronate 5-epimerase;
HG-5epi
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
[heparosan]-D-glucuronate 5-epimerase
Reaction(IUBMB)
[heparosan]-D-glucuronate = [acharan]-L-iduronate
Substrate
[heparosan]-D-glucuronate
Product
[acharan]-L-iduronate
Comment
The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.
History
EC 5.1.3.36 created 2015
Reference
1  [PMID:25677302]
  Authors
Mochizuki H, Yamagishi K, Suzuki K, Kim YS, Kimata K
  Title
Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme.
  Journal
Glycobiology. 25 (2015) 735-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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