KEGG   ENZYME: 5.2.1.12Help
Entry
EC 5.2.1.12                 Enzyme                                 

Name
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
Reaction(IUBMB)
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN:R09655]
Reaction(KEGG)
Substrate
9,15,9'-tricis-zeta-carotene [CPD:C19764]
Product
9,9'-dicis-zeta-carotene [CPD:C15857]
Comment
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
History
EC 5.2.1.12 created 2011
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K15744  
zeta-carotene isomerase
Genes
ATH: 
AT1G10830(Z-ISO)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj4g3v2573880.1(Lj4g3v2573880.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0014s14400g(POPTRDRAFT_572894)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os12t0405200-01(Os12g0405200)
OBR: 
BDI: 
ATS: 
ZMA: 
100194203(GRMZM2G011746)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
CSL: 
CVR: 
APRO: 
GSL: 
AAF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:20335404]
  Authors
Chen Y, Li F, Wurtzel ET
  Title
Isolation and characterization of the Z-ISO gene encoding a missing component of  carotenoid biosynthesis in plants.
  Journal
Plant. Physiol. 153 (2010) 66-79.
  Sequence
[ath:AT1G10830] [zma:100194203]
Reference
2  [PMID:17434985]
  Authors
Li F, Murillo C, Wurtzel ET
  Title
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization.
  Journal
Plant. Physiol. 144 (2007) 1181-9.
  Sequence
[zma:100194203]
Reference
3  [PMID:26075523]
  Authors
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET
  Title
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.
  Journal
Nat. Chem. Biol. 11 (2015) 598-605.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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