KEGG   ENZYME: 5.2.1.13Help
Entry
EC 5.2.1.13                 Enzyme                                 

Name
prolycopene isomerase;
CRTISO;
carotene cis-trans isomerase;
ZEBRA2 (gene name);
carotene isomerase;
carotenoid isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
7,9,7',9'-tetracis-lycopene cis-trans-isomerase
Reaction(IUBMB)
7,9,7',9'-tetracis-lycopene = all-trans-lycopene [RN:R07512]
Reaction(KEGG)
Substrate
7,9,7',9'-tetracis-lycopene [CPD:C15858]
Product
all-trans-lycopene [CPD:C05432]
Comment
Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.
History
EC 5.2.1.13 created 2011
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09835  
prolycopene isomerase
Genes
ATH: 
AT1G06820(CRTISO)
ALY: 
CRB: 
EUS: 
BRP: 
103843494(CRTISO1)
BNA: 
106420156(Crtiso)
THJ: 
CIT: 
102577949(CitCRTISO)
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0245759.1(Lj0g3v0245759.1) Lj0g3v0245759.2(Lj0g3v0245759.2)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
103486713(CISO)
RCU: 
JCU: 
POP: 
POPTR_0006s21410g(POPTRDRAFT_866125) POPTR_0016s06630g(POPTRDRAFT_904781)
VVI: 
SLY: 
101267857(CRTISO)
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os11t0572700-00(Os11g0572700)
OBR: 
BDI: 
SBI: 
SORBI_05g022240(SORBIDRAFT_05g022240)
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CME: 
PMK: 
PFV: 
PCH: 
PCZ: 
PCP: 
PSEM: 
MMT: 
MDN: 
MAH: 
OAI: 
GPB: 
DEU: 
DBW_2504(crtI)
BMX: 
DOL: 
DAL: 
AFW: 
SAMY: 
DTI: 
PGA: 
PGL: 
GTE: 
PPY: 
PPM: 
PPO: 
PPM_4688(crtI)
PPOL: 
PPQ: 
PPOY: 
PTA: 
PPEO: 
CBK: 
CBT: 
MGJ: 
MYG: 
NFA: 
SBH: 
KPL: 
KAL: 
SAQ: 
EYY: 
SYN: 
SYZ: 
SYY: 
SYNGTS_2835(sll0033)
SYT: 
SYNGTI_2834(sll0033)
SYS: 
SYNPCCN_2833(sll0033)
SYQ: 
SYNPCCP_2833(sll0033)
SYJ: 
SYW: 
SYNW0901(crtH)
SYC: 
SYF: 
SYD: 
SYE: 
SYG: 
sync_1140(crtH)
SYR: 
SYX: 
SYP: 
CYA: 
CYA_1857(crtH)
CYB: 
CYB_1298(crtH)
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
CGC: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
PMA: 
PMM: 
PMM1115(crtH)
PMT: 
PMN: 
PMI: 
PMB: 
PMC: 
PMF: 
PMG: 
PMH: 
PMJ: 
PME: 
PRC: 
PRM: 
AMR: 
MAR: 
MAE_12360(crtH)
MPK: 
CAN: 
CSN: 
HAO: 
GEN: 
GEE: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
CEP: 
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
CEO: 
STQ: 
SBU: 
SCC: 
SGP: 
LBI: 
LBF: 
CTM: 
FTE: 
CTE: 
CPC: 
CCH: 
CPH: 
CPB: 
CLI: 
PVI: 
PLT: 
PPH: 
PAA: 
CTS: 
MPG: 
 » show all
Taxonomy
Reference
1  [PMID:21209101]
  Authors
Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P
  Title
Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions.
  Journal
J. Biol. Chem. 286 (2011) 8666-76.
Reference
2  [PMID:20221689]
  Authors
Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C
  Title
Cloning and functional characterization of the maize carotenoid isomerase and beta-carotene hydroxylase genes and their regulation during endosperm maturation.
  Journal
Transgenic. Res. 19 (2010) 1053-68.
Reference
3  [PMID:11884678]
  Authors
Isaacson T, Ronen G, Zamir D, Hirschberg J
  Title
Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants.
  Journal
Plant. Cell. 14 (2002) 333-42.
  Sequence
[sly:101267857]
Reference
4  [PMID:21161331]
  Authors
Chai C, Fang J, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, Chu C
  Title
ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice.
  Journal
Plant. Mol. Biol. 75 (2011) 211-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system