KEGG ENZYME: 5.3.1.12

ENZYME: 5.3.1.12

Entry

EC 5.3.1.12 Enzyme

Name

glucuronate isomerase;
uronic isomerase;
uronate isomerase;
D-glucuronate isomerase;
uronic acid isomerase;
D-glucuronate ketol-isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds

Sysname

D-glucuronate aldose-ketose-isomerase

Reaction(IUBMB)

D-glucuronate = D-fructuronate [RN:R01482]

Reaction(KEGG)

R01482;
(other) R01983

Substrate

D-glucuronate [CPD:C00191]

Product

D-fructuronate [CPD:C00905]

Comment

Also converts D-galacturonate to D-tagaturonate.

Pathway

ec00040	Pentose and glucuronate interconversions
ec01100	Metabolic pathways

Orthology

K01812

glucuronate isomerase

Genes

ECO:	b3092(uxaC)
ECJ:	Y75_p3017(uxaC)
ECD:	ECDH10B_3268(uxaC)
EBW:	BWG_2802(uxaC)
ECOK:	ECMDS42_2562(uxaC)
ECE:	Z4445(uxaC)
ECS:	ECs3974
ECF:	ECH74115_4407(uxaC)
ETW:	ECSP_4066(uxaC)
ELX:	CDCO157_3715
EOJ:	ECO26_4195(uxaC)
EOI:	ECO111_3914(uxaC)
EOH:	ECO103_3837(uxaC)
ECG:	E2348C_3385(uxaC)
EOK:	G2583_3816(uxaC)
ELR:	ECO55CA74_18190
ECC:	c3850(uxaC)
ECP:	ECP_3183
ECI:	UTI89_C3530(uxaC)
ECV:	APECO1_3327(uxaC)
ECX:	EcHS_A3275(uxaC)
ECW:	EcE24377A_3560(uxaC)
ECM:	EcSMS35_3384(uxaC)
ECY:	ECSE_3373
ECR:	ECIAI1_3238(uxaC)
ECQ:	ECED1_3759(uxaC)
ECK:	EC55989_3506(uxaC)
ECT:	ECIAI39_3589(uxaC)
EOC:	CE10_3622(uxaC)
EUM:	ECUMN_3576(uxaC)
ECZ:	ECS88_3488(uxaC)
ELO:	EC042_3386(uxaC)
ELN:	NRG857_15390
ELH:	ETEC_3362
ESE:	ECSF_2935
ESO:	O3O_22150
ESM:	O3M_03535
ESL:	O3K_03495
ECL:	EcolC_0608
EBR:	ECB_02961(uxaC)
EBD:	ECBD_0648
EKO:	EKO11_0627
EKF:	KO11_07245(uxaC)
EAB:	ECABU_c35110(uxaC)
EDH:	EcDH1_0609
EDJ:	ECDH1ME8569_2987(uxaC)
EIH:	ECOK1_3522(uxaC)
ENA:	ECNA114_3185(uxaC)
ELU:	UM146_00855
EUN:	UMNK88_3848
ELW:	ECW_m3359(uxaC)
ELL:	WFL_16415(uxaC)
ELC:	i14_3541(uxaC)
ELD:	i02_3541(uxaC)
ELP:	P12B_c3208(uxaC)
EBL:	ECD_02961(uxaC)
EBE:	B21_02912(uxaC)
ELF:	LF82_2402(uxac)
ECOA:	APECO78_19265
EFE:	EFER_4383(uxaC)
EBT:	EBL_c04620(uxaC)
STY:	STY3308(uxaC)
STT:	t3058(uxaC)
SEX:	STBHUCCB_32260
STM:	STM3137
SEO:	STM14_3797
SEV:	STMMW_30971
SEY:	SL1344_3111(uxaC)
SEM:	STMDT12_C31920
SEJ:	STMUK_3125
SEB:	STM474_3287
SEF:	UMN798_3412(uxaC)
SETU:	STU288_15885
SPT:	SPA3005(uxaC)
SEK:	SSPA2803
SPQ:	SPAB_03917
SEI:	SPC_3205(uxaC)
SEC:	SC3078(uxaC)
SEH:	SeHA_C3383(uxaC)
SHB:	SU5_03635
SEE:	SNSL254_A3389(uxaC)
SEW:	SeSA_A3319(uxaC)
SEA:	SeAg_B3309(uxaC)
SED:	SeD_A3482(uxaC)
SEG:	SG3031
SEL:	SPUL_3143
SET:	SEN2980
SENJ:	CFSAN001992_17865
SES:	SARI_04489
SBG:	SBG_2733 SBG_2862
YPE:	YPO0579(uxaC)
YPK:	y3600(uxaC)
YPA:	YPA_3210
YPN:	YPN_0447 YPN_0448
YPM:	YP_2899(uxaC)
YPP:	YPDSF_0366
YPG:	YpAngola_A1104(uxaC)
YPZ:	YPZ3_0555(uxaC)
YPT:	A1122_02175
YPD:	YPD4_0507(uxaC)
YPX:	YPD8_0509(uxaC)
YPH:	YPC_4094(uxaC)
YPS:	YPTB3478(uxaC)
YPI:	YpsIP31758_0491(uxaC)
YPY:	YPK_0554
YPB:	YPTS_3663
YEN:	YE3708(uxaC)
YEP:	YE105_C3408
YEY:	Y11_25841
SFL:	SF3132(uxaC)
SFX:	S3339(uxaC)
SFV:	SFV_3133(uxaC)
SFE:	SFxv_3439(uxaC)
SSN:	SSON_3245(uxaC)
SSJ:	SSON53_18885
SBO:	SBO_2953(uxaC)
SBC:	SbBS512_E3528(uxaC)
ECA:	ECA0645(uxaC)
PCT:	PC1_0529
PCC:	PCC21_005470
PWA:	Pecwa_0746
PEC:	W5S_0644
EBI:	EbC_45830(uxaC)
PLU:	plu0176(uxaC)
PAY:	PAU_00126(uxaC)
ENT:	Ent638_3546
ENC:	ECL_02180 ECL_04492
ENO:	ECENHK_19285
ECLO:	ENC_33490
ESC:	Entcl_0604
EEC:	EcWSU1_03908(uxaC)
ENL:	A3UG_10220 A3UG_19855
EAS:	Entas_3772
EAE:	EAE_04000
EAR:	ST548_p3866
ESA:	ESA_03503
CSK:	ES15_3459
CSZ:	CSSP291_16265
CTU:	CTU_04620(uxaC)
KPN:	KPN_03520(uxaC)
KPU:	KP1_4818(uxaC)
KPM:	KPHS_46530
KPP:	A79E_0597
KPE:	KPK_0591(uxaC)
KPO:	KPN2242_20735
KVA:	Kvar_0579
KOX:	KOX_03380
CKO:	CKO_03735 CKO_04494
CRO:	ROD_14831(uxaC) ROD_47951(uxaC)
SPE:	Spro_4321
SRR:	SerAS9_4426
SRS:	SerAS12_4427
SRA:	SerAS13_4427
SMAF:	D781_4046
SMW:	SMWW4_v1c42830(uxaC)
EIC:	NT01EI_0502
ETR:	ETAE_0436(uxaC)
ETD:	ETAF_0389
ETC:	ETAC_01940
DDA:	Dd703_3385
DDC:	Dd586_0555 Dd586_2940
DDD:	Dda3937_02739(uxaC)
DZE:	Dd1591_3511
PAM:	PANA_3456(uxaC)
PLF:	PANA5342_0597(uxaC)
PAJ:	PAJ_2689(uxaC)
PAQ:	PAGR_g0577
PVA:	Pvag_2727(uxaC)
PAO:	Pat9b_3493
RAH:	Rahaq_3924
RAQ:	Rahaq2_4034
RAA:	Q7S_19955
MMK:	MU9_377
ROR:	RORB6_15970 RORB6_21770
EBF:	D782_0596
HIT:	NTHI0056(uxuC)
HIQ:	CGSHiGG_02740
HSO:	HS_1602(uxaC)
HSM:	HSM_0409
PUL:	NT08PM_1670
PMP:	Pmu_16080(uxaC)
MSU:	MS0544(uxaC)
APL:	APL_1020(uxaC)
APJ:	APJL_1038(uxaC)
APA:	APP7_1077
ASU:	Asuc_0145
AAO:	ANH9381_1877
AAN:	D7S_01865
GAN:	UMN179_01772
XCC:	XCC4117(hrmI)
XCB:	XC_4209
XCA:	xccb100_4329(uxaC)
XCV:	XCV4357(uxaC)
XCP:	XCR_4439(uxaC)
XAC:	XAC4251(hrmI)
XAX:	XACM_4124(hrmI)
XAO:	XAC29_21445
XOO:	XOO4427(hrmI)
XOM:	XOO_4170
XOP:	PXO_03860(uxaC)
XOR:	XOC_4583(uxaC)
XAL:	XALc_0035(uxaC)
XCI:	XCAW_00046(uxaC)
PSU:	Psesu_2911
VVU:	VV2_1070
VVY:	VVA1594
VVM:	VVMO6_04462
VPA:	VPA1706
VFU:	vfu_B01474
PPR:	PBPRB1515
CJA:	CJA_2772(uxaC)
SDE:	Sde_0940 Sde_1272
AMAC:	MASE_11305
AMB:	AMBAS45_11920
AMG:	AMEC673_11660
AMK:	AMBLS11_11155
GPS:	C427_2362
PIN:	Ping_0131
PSY:	PCNPT3_06910
TTU:	TERTU_0898(uxaC)
FCF:	FNFX1_0910
FCN:	FN3523_0894
FRT:	F7308_1394
MMW:	Mmwyl1_2780
TAU:	Tola_2882 Tola_3025
SAGA:	M5M_10300
GME:	Gmet_0451
MLO:	mll4056
MCI:	Mesci_1182
MOP:	Mesop_1213
MAM:	Mesau_01231
MES:	Meso_4496
SME:	SM_b21354(uxaC)
SMK:	Sinme_4778
SMQ:	SinmeB_3737
SMX:	SM11_pD0668(uxaC)
SMI:	BN406_05731(uxaC)
SMEG:	C770_GR4pD0651
SMEL:	SM2011_b21354(uxaC)
SMD:	Smed_4749
AVI:	Avi_3892
RET:	RHE_CH00090(uxaC)
REC:	RHECIAT_CH0000094(uxaC)
RLE:	RL0099
RLT:	Rleg2_4023
RLG:	Rleg_4353
BME:	BMEII0476 BMEII0477
BMZ:	BM28_B0781(uxaC) BM28_B0782
BMG:	BM590_B0779(uxaC) BM590_B0780
BMW:	BMNI_II0760 BMNI_II0761
BMC:	BAbS19_II03990 BAbS19_II04000
BAA:	BAA13334_II00902 BAA13334_II00903
BMS:	BRA0812
BSI:	BS1330_II0805
BMT:	BSUIS_B0804
BSV:	BSVBI22_B0804
BCS:	BCAN_B0827(uxaC)
BSK:	BCA52141_II0046
BMR:	BMI_II806
BPP:	BPI_II868
AZC:	AZC_3342
PHL:	KKY_2612
CCR:	CC_1490
CCS:	CCNA_01557
CAK:	Caul_1756
CSE:	Cseg_1551
PZU:	PHZ_c2452
BSB:	Bresu_1683
AEX:	Astex_0450
SIT:	TM1040_3865
RSP:	RSP_0488(uxaC)
RSH:	Rsph17029_2139
RSQ:	Rsph17025_2412
RSK:	RSKD131_1820
RDE:	RD1_2934(uxaC)
RLI:	RLO149_c015060
KVU:	EIO_3036
KVL:	KVU_PA0208(uxaC)
PSF:	PSE_p0105(uxaC)
OAT:	OAN307_c00330
MMR:	Mmar10_0230
HBA:	Hbal_2766
NAR:	Saro_3523 Saro_3677
NPP:	PP1Y_Mpl4762
SAL:	Sala_3046
SWI:	Swit_1887
SPHM:	G432_12090
SJP:	SJA_C2-03420(uxaC)
SCH:	Sphch_3091
AZL:	AZL_d01370(uxaC)
ALI:	AZOLI_p40500(uxaC)
ABS:	AZOBR_p460005(uxaC)
APB:	SAR116_0902
PGV:	SL003B_2441
BSU:	BSU12300(uxaC)
BSR:	I33_1385(uxaC)
BSL:	A7A1_0239
BSH:	BSU6051_12300(uxaC)
BSY:	I653_06275
BSS:	BSUW23_06265(uxaC)
BST:	GYO_1539(uxaC)
BSO:	BSNT_02087(uxaC)
BSN:	BSn5_18120
BSQ:	B657_12300(uxaC)
BSUB:	BEST7613_1227(uxaC)
BSX:	C663_1262(uxaC)
BLI:	BL00708(uxaC)
BLD:	BLi03516(uxaC)
BAO:	BAMF_1319(uxaC)
BAY:	RBAM_012380(uxaC)
BAQ:	BACAU_1190(uxaC)
BYA:	BANAU_1172(uxaC)
BAMP:	B938_06320
BAML:	BAM5036_1145(uxaC)
BAZ:	BAMTA208_10990(uxaC)
BQL:	LL3_01327(uxaC)
BXH:	BAXH7_02249(uxaC)
BQY:	MUS_1320(uxaC)
BAMI:	KSO_013380
BAE:	BATR1942_03815
BHA:	BH0705
BCL:	ABC0995(uxaC)
BPU:	BPUM_2987(uxaC)
BMQ:	BMQ_3434(uxaC)
BMD:	BMD_3425(uxaC)
BMH:	BMWSH_1755 BMWSH_3361(uxaC)
BCO:	Bcell_0550
BAG:	Bcoa_2241
BJS:	MY9_1344
OIH:	OB0367
GTN:	GTNG_1765(uxaC)
GTH:	Geoth_2254
GCT:	GC56T3_1651
GMC:	GY4MC1_2134
GGH:	GHH_c19310(uxaC)
AXL:	AXY_02770(uxaC)
SHA:	SH2648
SWA:	A284_11490
PJD:	Pjdr2_2923
GYM:	GYMC10_4123 GYMC10_4746
PPY:	PPE_02047
PPM:	PPSC2_c2283
PPO:	PPM_2053(uxaC)
PMS:	KNP414_05884(uxaC)
PMQ:	PM3016_5223
PMW:	B2K_27020
PTA:	HPL003_10410 HPL003_19105
TCO:	Theco_1251
SIV:	SSIL_3025
LLA:	L0019(uxaC)
LLK:	LLKF_1710(uxaC) LLKF_1785(uxaC)
LLT:	CVCAS_1536(uxaC)
LLS:	lilo_1554(uxaC)
LLC:	LACR_1742
LLM:	llmg_0862(uxaC)
LLR:	llh_4335 llh_4340
LLN:	LLNZ_04430
LLI:	uc509_1577(uxaC)
SPH:	MGAS10270_Spy1171
SNM:	SP70585_2238(uxaC)
SAG:	SAG0701(uxaC)
SAN:	gbs0674
SAK:	SAK_0827(uxaC)
SGC:	A964_0700(uxaC)
SAGS:	SaSA20_0583(uxaC)
SSU:	SSU05_1158 SSU05_1159
SSV:	SSU98_1174
SSB:	SSUBM407_0783(uxaC)
SSI:	SSU1003(uxaC)
SSS:	SSUSC84_1041(uxaC)
SST:	SSUST3_1180(uxaC)
SSF:	SSUA7_1016(uxaC)
SSK:	SSUD12_0771(uxaC)
SSQ:	SSUD9_1324(uxaC)
SSW:	SSGZ1_1020
SUI:	SSUJS14_1130
SUO:	SSU12_1068(uxaC)
SRP:	SSUST1_0797
SUP:	YYK_04765
SSUS:	NJAUSS_1076
SEQ:	SZO_13120
SEZ:	Sez_0689
SEZO:	SeseC_00841(uxaC)
SEU:	SEQ_0716
SUB:	SUB1203(uxaC)
SDS:	SDEG_1363
SDG:	SDE12394_07310
SDA:	GGS_1276
SDC:	SDSE_1441(uxaC)
STB:	SGPB_0959(uxaC)
LSA:	LSA0129(uxaC)
LBR:	LVIS_0135 LVIS_0150
LBK:	LVISKB_0134 LVISKB_0149
LRH:	LGG_00054(uxaC) LGG_00055(uxaC)
LRG:	LRHM_0054 LRHM_0055
LRL:	LC705_00046(uxaC)
LRA:	LRHK_50
LBH:	Lbuc_2108
LBN:	LBUCD034_2207(uxaC)
EFC:	EFAU004_02548
EFU:	HMPREF0351_12490(uxaC)
EFM:	M7W_2506
ECAS:	ECBG_02098 ECBG_02655
MPS:	MPTP_1938
MPX:	MPD5_1732
CRN:	CAR_c20880(uxaC)
CAC:	CA_C0692(uxaC)
CAE:	SMB_G0706(uxaC)
CAY:	CEA_G0703(uxaC)
CPE:	CPE0152(uxaC)
CBE:	Cbei_1832 Cbei_4082 Cbei_4657
CPY:	Cphy_2743
CCE:	Ccel_1676
CSH:	Closa_1651
CCB:	Clocel_2249
CLB:	Clo1100_0227
CCL:	Clocl_3004
CSR:	Cspa_c33440(uxaC2) Cspa_c48860(uxaC3) Cspa_c49430(uxaC4)
CSS:	Cst_c21160(uxaC)
CSD:	Clst_2021(uxaC)
AMT:	Amet_1291
DAI:	Desaci_1149
APR:	Apre_1600
EEL:	EUBELI_00905
ERA:	ERE_09600
BPB:	bpr_I1591(uxaC)
BFI:	CIY_24160
CLE:	Clole_1214
RHO:	RHOM_08225
RIX:	RO1_13490
RIM:	ROI_24040
RAL:	Rumal_2175
FPR:	FP2_23370
FPA:	FPR_15620
TTE:	TTE1939(UxaC)
TIT:	Thit_0180 Thit_1741
TMT:	Tmath_0237 Tmath_1721
CSC:	Csac_1949
ATE:	Athe_1402
COB:	COB47_1151
CHD:	Calhy_1333
COW:	Calow_1181
CKI:	Calkr_1388
CKN:	Calkro_1307
CLC:	Calla_0773
TTM:	Tthe_2404
TTO:	Thethe_02454
TXY:	Thexy_2056
TSH:	Tsac_0170
HAS:	Halsa_0912
SRI:	SELR_01340(uxaC) SELR_02180(uxaC)
MED:	MELS_0552
CGL:	NCgl2398(Cgl2484)
CGB:	cg2731(uxaC)
CGU:	WA5_2398(UxaC)
CGT:	cgR_2394
CEF:	CE2377
CHN:	A605_11465
LXX:	Lxx17350(uxaC)
ART:	Arth_0502
AAU:	AAur_0527(uxaC)
ACH:	Achl_0787
APN:	Asphe3_06840
ARR:	ARUE_c04980(uxaC)
RSA:	RSal33209_3421
BCV:	Bcav_3312
BFA:	Bfae_31050
JDE:	Jden_2405
XCE:	Xcel_2650
IVA:	Isova_0464
SKE:	Sked_05310
CFL:	Cfla_0879 Cfla_3012
CFI:	Celf_3292
ICA:	Intca_2464
PAC:	PPA2329
PAK:	HMPREF0675_5409(uxaC)
PAV:	TIA2EST22_11535
PAX:	TIA2EST36_11395
PAZ:	TIA2EST2_11340
PAW:	PAZ_c24300(uxaC)
PAD:	TIIST44_04490
PCN:	TIB1ST10_11860
PACC:	PAC1_11885
PACH:	PAGK_2237
PBO:	PACID_03010(uxaC) PACID_03730
PRA:	PALO_10645
MPH:	MLP_05690(uxaC)
KFL:	Kfla_2754
FRE:	Franean1_3197
FRI:	FraEuI1c_5658
MMAR:	MODMU_2195(uxaC) MODMU_3045(uxaC)
KRA:	Krad_0587
SEN:	SACE_5055(hrmI)
SVI:	Svir_07080
MAU:	Micau_3548
MIL:	ML5_4848
VMA:	VAB18032_24025
AMS:	AMIS_46540 AMIS_55120
ASE:	ACPL_5381(uxaC)
AHE:	Arch_0436
BLN:	Blon_0669
BLON:	BLIJ_0679
BAST:	BAST_1371
CGO:	Corgl_0555
TBE:	Trebr_0017
TAZ:	TREAZ_2384(uxaC)
TPI:	TREPR_0589(uxaC)
STA:	STHERM_c04600
STQ:	Spith_0417
SCC:	Spico_0046
SCD:	Spica_0630
BHY:	BHWA1_02239(uxaC)
BRM:	Bmur_2037
BPO:	BP951000_0480(uxaC)
BPJ:	B2904_orf911
BPIP:	BPP43_00615
BPW:	WESB_1774(uxaC)
BIP:	Bint_2442(uxaC)
SBU:	SpiBuddy_3012
SGP:	SpiGrapes_1977
ABA:	Acid345_4306
ACA:	ACP_2685(uxaC)
ACM:	AciX9_2075
GMA:	AciX8_1656
TSA:	AciPR4_1685
TRS:	Terro_4315
SUS:	Acid_5330
BTH:	BT_0823
BFR:	BF2293
BFS:	BF2382(uxaC)
BFG:	BF638R_2394(uxaC)
BVU:	BVU_3074
BHL:	Bache_2336
BSA:	Bacsa_0709
BXY:	BXY_05560
PDI:	BDI_3184
PPN:	Palpr_0559
TFO:	BFO_1156(uxaC)
APS:	CFPG_235
PRU:	PRU_1363(uxaC)
PDT:	Prede_2325
ASH:	AL1_02740
RMR:	Rmar_2303
RMG:	Rhom172_2302
CPI:	Cpin_5502
NKO:	Niako_5295
PHE:	Phep_1162
PSN:	Pedsa_2719
SHG:	Sph21_0575 Sph21_2894
HHY:	Halhy_4400
CMR:	Cycma_2706
BBD:	Belba_2487
EVI:	Echvi_3072 Echvi_3102
DFE:	Dfer_4124
SLI:	Slin_1060 Slin_4786
LBY:	Lbys_1618
RSI:	Runsl_2283
EOL:	Emtol_2698
FAE:	FAES_4823(uxaC)
FJO:	Fjoh_4262
FBR:	FBFL15_2674(uxaC)
RBI:	RB2501_03985
ZPR:	ZPR_3035
FBC:	FB2170_10646
ZGA:	zobellia_1577(uxaC)
MRS:	Murru_2759
NDO:	DDD_0346
FBA:	FIC_01890
STR:	Sterm_0693
SMF:	Smon_1307
OTE:	Oter_4293
CAA:	Caka_2860
PLM:	Plim_2160
PBS:	Plabr_2665
IPA:	Isop_0287 Isop_2134
SACI:	Sinac_4562 Sinac_6593
PHM:	PSMK_10970(uxaC)
RSD:	TGRD_067
NPU:	Npun_F5333
CAP:	CLDAP_29610(uxaC)
TRA:	Trad_0657
TMA:	TM0064
TPT:	Tpet_0860
TLE:	Tlet_1289
TRQ:	TRQ2_0883
TNA:	CTN_0630
TNP:	Tnap_0694
TTA:	Theth_0974
PMO:	Pmob_0854
MPG:	Theba_0060
HUT:	Huta_0158 Huta_0870
HTU:	Htur_4204
HXA:	Halxa_3777
IAG:	Igag_0947
CMA:	Cmaq_1622

» show all

Reference

1 [PMID:13794771]

Authors

ASHWELL G, WAHBA AJ, HICKMAN J.

Title

Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli.

Journal

J. Biol. Chem. 235 (1960) 1559-65.

Organism

Escherichia coli [GN:eco]

Reference

2 [PMID:14409051]

Authors

KILGORE WW, STARR MP.

Title

Catabolism of galacturonic and glucuronic acids by Erwinia carotovora.

Journal

J. Biol. Chem. 234 (1959) 2227-35.

Organism

Erwinia carotovora [GN:eca]

Other DBs

ExplorEnz - The Enzyme Database:

5.3.1.12

IUBMB Enzyme Nomenclature:

5.3.1.12

ExPASy - ENZYME nomenclature database:

5.3.1.12

BRENDA, the Enzyme Database:

5.3.1.12

CAS:

9023-87-4

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