KEGG   ENZYME: 5.3.2.5Help
Entry
EC 5.3.2.5                  Enzyme                                 

Name
2,3-diketo-5-methylthiopentyl-1-phosphate enolase;
DK-MTP-1-P enolase;
MtnW;
YkrW;
RuBisCO-like protein;
RLP
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
BRITE hierarchy
Sysname
2,3-diketo-5-methylthiopentyl-1-phosphate keto---enol-isomerase
Reaction(IUBMB)
5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate [RN:R07393]
Reaction(KEGG)
Substrate
5-(methylthio)-2,3-dioxopentyl phosphate [CPD:C15650]
Product
2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate [CPD:C15651]
Comment
The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2].
In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 3.1.3.87, 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [1].
History
EC 5.3.2.5 created 2012
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Orthology
K08965  
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
Genes
AFE: 
AFR: 
AFE_0434(ccbL2)
ACU: 
AFI: 
BSU: 
BSU13590(mtnW)
BSR: 
I33_1530(mtnW)
BSL: 
BSH: 
BSY: 
BSS: 
BST: 
GYO_1686(mtnW)
BSO: 
BSN: 
BSQ: 
BSUB: 
BSX: 
C663_1400(mtnW)
BSP: 
BLI: 
BL03540(mtnW)
BLD: 
BLi01515(mtnW)
BLH: 
BAO: 
BAMF_1441(mtnW)
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
RBAU_1315(mtnW)
BAMN: 
BASU_1294(mtnW)
BAMB: 
BAZ: 
BQL: 
LL3_01461(mtnW)
BXH: 
BQY: 
MUS_1440(mtnW)
BAMI: 
BAMC: 
BAMF: 
BAE: 
BAN: 
BA_4255(mtnW)
BAR: 
GBAA_4255(mtnW)
BAT: 
BAS3946(mtnW)
BAH: 
BAI: 
BAA_4278(mtnW)
BAX: 
BANT: 
BANR: 
BAL: 
BCE: 
BC4036(mtnW)
BCA: 
BCZ: 
BCZK3793(mtnW)
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCQ_3826(mtnW)
BCX: 
BCA_4149(mtnW)
BNC: 
BCF: 
BCER: 
BCK_15020(mtnW)
BCY: 
BTK: 
BTL: 
BALH_3653(mtnW)
BTB: 
BTT: 
BTC: 
BTF: 
BTM: 
BTG: 
BTI: 
BTG_29240(mtnW)
BTN: 
BTHT: 
BTHU: 
BWE: 
BTY: 
BCL: 
ABC1775(mtnW)
BPU: 
BPUM_1252(mtnW)
BPF: 
BMQ: 
BMQ_1250(mtnW)
BMD: 
BMD_1234(mtnW)
BMH: 
BJS: 
BIF: 
GKA: 
GK0953(mtnW)
GTN: 
GTNG_0841(mtnW)
GTE: 
GWC: 
GYC: 
GYA: 
GCT: 
GMC: 
GGH: 
GJF: 
AFL: 
Aflv_1997(mtnW)
ESI: 
Exig_0430(mtnW)
EAT: 
EAN: 
Eab7_0405(mtnW)
EXM: 
BBE: 
PJD: 
GYM: 
PPY: 
PPM: 
PPO: 
PPM_2881(ykrW)
PPOL: 
PMS: 
PMQ: 
PTA: 
PLV: 
TCO: 
AAC: 
Aaci_0096(mtnW)
AAD: 
TC41_0117(mtnW)
SAY: 
TPY_2539(mtnW)
SAP: 
TEP: 
TAE: 
TPZ: 
NML: 
MAR: 
CYP: 
CYC: 
CYH: 
CYJ: 
GEI: 
MIC: 
ARP: 
CALT: 
RIV: 
PLP: 
SCS: 
PMX: 
LFC: 
LFI: 
MOX: 
DAMO_2930(mtnW)
AFU: 
AF1587(rbcL-1)
 » show all
Taxonomy
Reference
1  [PMID:8227039]
  Authors
Myers RW, Wray JW, Fish S, Abeles RH.
  Title
Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae.
  Journal
J. Biol. Chem. 268 (1993) 24785-91.
  Organism
Klebsiella pneumoniae
Reference
2  [PMID:14551435]
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science. 302 (2003) 286-90.
  Organism
Bacillus subtilis
  Sequence
[up:O31666]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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