| Entry |
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| Name |
polyenoic fatty acid isomerase;
PFI;
eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase;
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase (incorrect);
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
 |
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| Sysname |
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming)
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| Reaction(IUBMB) |
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate [RN: R06502]
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| Reaction(KEGG) |
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| Substrate |
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate
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| Product |
(5Z,7E,9E,14Z,17Z)-icosapentaenoate
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| Comment |
The enzyme from the red alga Ptilota filicina catalyses the isomerization of skip dienes (methylene-interrupted double bonds) in a broad range of fatty acids and fatty-acid analogues, such as arachidonate and gamma-linolenate, to yield a conjugated triene.
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| History |
EC 5.3.3.13 created 2004
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| Orthology |
| polyenoic fatty acid isomerase |
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| Reference |
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| Authors |
Wise ML, Hamberg M, Gerwick WH. |
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| Title |
Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina. |
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| Journal |
Biochemistry. 33 (1994) 15223-32. |
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| Sequence |
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| Reference |
|
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| Authors |
Wise ML, Soderstrom K, Murray TF, Gerwick WH. |
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| Title |
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. |
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| Journal |
Experientia. 52 (1996) 88-92. |
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| Reference |
|
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| Authors |
Wise ML, Rossi J, Gerwick WH. |
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| Title |
Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina. |
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| Journal |
Biochemistry. 36 (1997) 2985-92. |
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| Sequence |
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| Reference |
|
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| Authors |
Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH. |
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| Title |
Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA. |
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| Journal |
Arch. Biochem. Biophys. 401 (2002) 11-20. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 159002-84-3 |
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