| Entry |
|
|---|
| Name |
trans-2-decenoyl-[acyl-carrier protein] isomerase;
beta-hydroxydecanoyl thioester dehydrase;
trans-2-cis-3-decenoyl-ACP isomerase;
trans-2,cis-3-decenoyl-ACP isomerase;
trans-2-decenoyl-ACP isomerase;
FabM;
decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase
|
|---|
| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
 |
|---|
| Sysname |
decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase
|
|---|
| Reaction(IUBMB) |
a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein] [RN: R07639]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
trans-dec-2-enoyl-[acyl-carrier protein] [CPD: C05754]
|
|---|
| Product |
cis-dec-3-enoyl-[acyl-carrier protein]
|
|---|
| Comment |
While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.
|
|---|
| Reference |
|
|---|
| Authors |
Brock DJ, Kass LR, Bloch K. |
|---|
| Title |
Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action. |
|---|
| Journal |
J. Biol. Chem. 242 (1967) 4432-40. |
|---|
| Organism |
Escherichia coli [GN: eco] |
|---|
| Reference |
2 |
|---|
| Authors |
Bloch, K. |
|---|
| Title |
Enzymatic synthesis of monounsaturated fatty acids. |
|---|
| Journal |
Acc. Chem. Res. 2 (1969) 193-202. |
|---|
| Reference |
|
|---|
| Authors |
Marrakchi H, Choi KH, Rock CO. |
|---|
| Title |
A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae. |
|---|
| Journal |
J. Biol. Chem. 277 (2002) 44809-16. |
|---|
| Organism |
Streptococcus pneumoniae |
|---|
| Reference |
4 |
|---|
| Authors |
Cronan, J.E., Jr. and Rock, C.O. |
|---|
| Title |
Biosynthesis of membrane lipids. |
|---|
| Journal |
In: Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9030-80-2 |
|---|
