KEGG   ENZYME: 5.3.3.17Help
Entry
EC 5.3.3.17                 Enzyme                                 

Name
trans-2,3-dihydro-3-hydroxyanthranilate isomerase;
phzF (gene name);
(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase (incorrect)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase
Reaction(IUBMB)
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [RN:R09707]
Reaction(KEGG)
Substrate
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate
Product
(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [CPD:C19831]
Comment
The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate
History
EC 5.3.3.17 created 2011
Pathway
ec00405  Phenazine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K06998  trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Genes
ENO: ECENHK_09880
ECLE: ECNIH2_10560
ECLN: ECNIH4_12765
EAS: Entas_2255
EAU: DI57_08995
EHM: AB284_15100
EKB: BFV64_10295
ELG: BH714_01675
KIN: AB182_10945
LAX: APT61_10450
SMAF: D781_2303
ECA: ECA2699(ehpD)
PATR: EV46_13185
PATO: GZ59_18610(ehpD)
PAJ: PAJ_0937
LAQ: GLA29479_2363(phzF)
PAE: PA1904(phzF2) PA4215(phzF1)
PAEV: N297_1964(phzF) N297_4347(phzF)
PAEI: N296_1964(phzF) N296_4347(phzF)
PAU: PA14_09420(phzF1) PA14_39890(phzF2)
PAG: PLES_07121(phzF1) PLES_34201(phzF2)
PAF: PAM18_0722(phzF1) PAM18_3138(phzF2)
PNC: NCGM2_2821(phzF2) NCGM2_5460(phzF2)
PAEB: NCGM1900_0744(phzF2) NCGM1900_4585(phzF2)
PAEL: T223_17480
PAEU: BN889_04686(phzF1_1) BN889_06989(phzF1_2)
PAEC: M802_1962(phzF) M802_4345(phzF)
PAEO: M801_1963(phzF) M801_4213(phzF)
PFB: VO64_0339
SVO: SVI_2626
SPSW: Sps_01493
CYQ: Q91_0813
HEL: HELO_1064
HAM: HALO0728
HCO: LOKO_00358(phzF)
ABO: ABO_0952
SLIM: SCL_2766
BGU: KS03_4990(phzF)
BPT: Bpet0841
AXX: ERS451415_02093(phzF_2)
CCRO: CMC5_007820(phzF)
MLO: mll1393
MES: Meso_1499
SFH: SFHH103_01857(phzf1) SFHH103_02823(phzf3)
ATU: Atu1346
ARA: Arad_2852 Arad_3737(phzF)
AVI: Avi_2772
AGR: AGROH133_05795(phzF)
RHT: NT26_2078
BME: BMEI0630
BMEL: DK63_796
BMEE: DK62_60
BABO: DK55_1364
BABR: DO74_527
BABT: DK49_1120
BABB: DK48_756
BABU: DK53_1347
BABS: DK51_113
BABC: DO78_1268
BMS: BR1374
BSZ: DK67_929
BOV: BOV_1331
BCAR: DK60_1407
BCAS: DA85_06585
BMR: BMI_I1384
BPP: BPI_I1424
BPV: DK65_14
OAN: Oant_1819
OAH: DR92_1304
BJA: bll5643
BRS: S23_26080
BRAD: BF49_6001
RPA: RPA3182(phzF)
RPC: RPC_3359
RPT: Rpal_3592
VGO: GJW-30_1_01905(phzF)
XAU: Xaut_1326
AZC: AZC_1065
SNO: Snov_2310
MEX: Mext_2671
MDI: METDI3430
MCH: Mchl_2898
MET: M446_1440
MPO: Mpop_2793
MNO: Mnod_0956
MOR: MOC_1374(phzF)
META: Y590_12835
HDN: Hden_2074
RVA: Rvan_3310
PHL: KKY_1922
DEQ: XM25_10725(like)
MMED: Mame_03132(phzF)
MCG: GL4_2770
HDI: HDIA_2852(phzF)
JAN: Jann_1138
DSH: Dshi_2745
PSF: PSE_4223
CID: P73_1721
SPSE: SULPSESMR1_02390(yddE)
AHT: ANTHELSMS3_02186(phzF)
SPHI: TS85_01540
SPHD: HY78_15755
GOH: B932_1690
TMO: TMO_2115
BLI: BL02714
BLD: BLi00185
BHA: BH1964
BMYO: BG05_3678
BMQ: BMQ_3274
BMD: BMD_3277
BMEG: BG04_191
BEO: BEH_15810
CBO: CBO2183
CBA: CLB_2121
CBH: CLC_2125
CBY: CLM_2382
CBB: CLD_2399
CBI: CLJ_B2388
CBF: CLI_2226
CBM: CBF_2211
SAY: TPY_3722
SALS: SLNWT_0235
STRD: NI25_24420
NDA: Ndas_5032
GOB: Gobs_1135
MMAR: MODMU_1194
PDX: Psed_1045
PSEA: WY02_21385
PSEE: FRP1_21810
PSEH: XF36_20175
SESP: BN6_08900
ALL: CRK58744
SAQ: Sare_0665
MIL: ML5_0918
ASE: ACPL_7836
ACTN: L083_7616
AFS: AFR_40040
SNA: Snas_2025
TBI: Tbis_2951
SYN: slr1019
SYZ: MYO_15810
SYY: SYNGTS_0576(slr1019)
SYT: SYNGTI_0576(slr1019)
SYS: SYNPCCN_0576(slr1019)
SYQ: SYNPCCP_0576(slr1019)
MAR: MAE_13230
MPK: VL20_1880
CYL: AA637_08425(phzF)
CYT: cce_1558
TER: Tery_1075
GLJ: GKIL_1030
CEO: ETSB_1306
CAU: Caur_2870
STI: Sthe_3051
TRA: Trad_1434
ACA: ACP_2558
GAU: GAU_3074
GBA: J421_2058
SLI: Slin_1604
FAE: FAES_4899(phzF)
HSW: Hsw_1756
FJO: Fjoh_2247
FJG: BB050_00394(phzF) BB050_01726(yddE)
NDE: NIDE2777(yddE)
NMV: NITMOv2_1732(yddE)
NIO: NITINOP_2909(yddE)
NJA: NSJP_3609(yddE)
MPD: MCP_2170
RCI: RRC1
FPL: Ferp_0800
HAL: VNG_6408G(phzF)
HSL: OE_6093F(phzF2)
HMA: rrnAC2502(phzC)
HHI: HAH_2933(phzC)
HVO: HVO_0143(phzF)
HME: HFX_0152(phzC)
LOKI: Lokiarch_48980(phzF)
 » show all
Taxonomy
Reference
1  [PMID:15449932]
  Authors
Parsons JF, Song F, Parsons L, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79.
  Journal
Biochemistry. 43 (2004) 12427-35.
  Sequence
Reference
2  [PMID:15545603]
  Authors
Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV
  Title
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16431-6.
  Sequence
Reference
3  [PMID:15502343]
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure of the phenazine biosynthesis enzyme PhzG.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 2110-3.
Reference
4  [PMID:14684924]
  Authors
Mavrodi DV, Bleimling N, Thomashow LS, Blankenfeldt W
  Title
The purification, crystallization and preliminary structural characterization of  PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 184-6.
Reference
5  [PMID:19053436]
  Authors
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W
  Title
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
  Journal
J. Am. Chem. Soc. 130 (2008) 17053-61.
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.17
IUBMB Enzyme Nomenclature: 5.3.3.17
ExPASy - ENZYME nomenclature database: 5.3.3.17
BRENDA, the Enzyme Database: 5.3.3.17

DBGET integrated database retrieval system